Evolution and Morphogenesis of Differentiated Multicellular Organisms - Autonomously Generated Diffusion Gradients for Positional Information
Evolution and Morphogenesis of Differentiated Multicellular Organisms - Autonomously Generated Diffusion Gradients for Positional Information
复制标题
分化多细胞生物的进化和形态发生 - 自主生成位置信息的扩散梯度
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Chrystopher L. Nehaniv
中科院分区：
文献类型：
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作者：
Johannes F. Knabe;M. Schilstra;Chrystopher L. Nehaniv
发育是一个强大的过程，涉及基因组从一个卵细胞转化为具有许多细胞类型的多细胞生物体。分裂的细胞设法以可靠的方式组织和分配自己特殊的、分化的角色，创造时空模式和劳动分工。这尽管事实上，很少的位置信息可以提供给他们最初引导这种模式。受发育生物学家L. Wolpert，我们在进化环境中模拟这种情况，个体必须成长为“法国国旗”模式。在我们的模型中的细胞存在于一个2层的Potts模型的物理环境。由连续的遗传调控网络控制，对于一个个体的所有细胞都是相同的，细胞可以在参数上单独不同，包括靶体积，形状，方向和扩散。细胞间的通讯是可能的，通过分泌和传感的扩散形态。从单个细胞生长的进化个体可以通过建立和维持不对称的形态梯度来发展法国国旗模式-这是几种理论模型预测的行为。
Development is the powerful process involving a genome in the transformation from one egg cell to a multicellular organism with many cell types. The dividing cells manage to organize and assign themselves special, differentiated roles in a reliable manner, creating a spatio-temporal pattern and division of labor. This despite the fact that little positional information may be available to them initially to guide this patterning. Inspired by a model of developmental biologist L. Wolpert, we simulate this situation in an evolutionary setting where individuals have to grow into “French flag” patterns. The cells in our model exist in a 2-layer Potts model physical environment. Controlled by continuous genetic regulatory networks, identical for all cells of one individual, the cells can individually differ in parameters including target volume, shape, orientation, and diffusion. Intercellular communication is possible via secretion and sensing of diffusing morphogens. Evolved individuals growing from a single cell can develop the French flag pattern by setting up and maintaining asymmetric morphogen gradients ‐ a behavior predicted by several theoretical models.
影响因子：
2.7
作者：
Merks, RMH;Brodsky, SV;Glazier, JA
通讯作者：
Glazier, JA
影响因子：
4
作者：
Jaeger, Johannes;Reinitz, John
通讯作者：
Reinitz, John