Pharmacology of brain epinephrine neurons.
Pharmacology of brain epinephrine neurons.
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脑肾上腺素神经元的药理学。
DOI：
10.1146/annurev.pa.22.040182.000335
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发表时间：
1982
影响因子：
12.5
通讯作者：
R. Fuller
中科院分区：
文献类型：
--
作者：
R. Fuller
含有PNMT（肾上腺素形成酶）的神经元在大鼠大脑的脑干区域具有它们的细胞体，并且主要将投射发送到其他脑干区域、下丘脑和脊髓。这些神经元可能会受到各种药物的影响。肾上腺素神经元系统可能在MAO抑制剂和摄取抑制剂以及α和β激动剂和拮抗剂的某些药理作用中发挥作用。PNMT抑制剂目前代表了修饰肾上腺素神经元而不改变脑中的去甲肾上腺素或多巴胺神经元的唯一手段。对影响肾上腺素神经元的药物的继续研究将有助于阐明这些神经元的功能。影响肾上腺素神经元的药物可用于治疗高血压、精神疾病、神经内分泌功能障碍以及可能的其他疾病。
Neurons that contain PNMT, the epinephrine-forming enzyme, have their cell bodies in brain stem regions in rat brain and send projections mainly into other brain stem areas, hypothalamus, and spinal cord. These neurons can be affected pharmacologically by various kinds of drugs. Epinephrine neuronal systems might play a part in some pharmacologic actions of MAO inhibitors and uptake inhibitors as well as alpha and beta agonists and antagonists. PNMT inhibitors currently represent the only means of modifying epinephrine neurons pharmacologically without also altering norepinephrine or dopamine neurons in brain. The continued study of drugs affecting epinephrine neurons should be useful in elucidating functions of these neurons. Drugs that affect epinephrine neurons may be of use in the treatment of hypertension, psychiatric disorders, neuroendocrine dysfunction, and possibly other diseases.
大鼠皮质酮释放的中枢表能抑制。
影响因子：
6.1
作者：
Roth,KA;Katz,RJ;Sibel,M;Mefford,IN;Barchas,JD;Carroll,BJ
通讯作者：
Carroll,BJ