The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study.
The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study.
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重组人表皮生长因子对直肠癌和肛门癌患者放射性皮炎的影响：一项自我对照研究
DOI：
10.1186/s12885-022-10226-x
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发表时间：
2022-11-05
期刊：
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
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作者：
BackgroundOur previous study reported that recombinant human epidermal growth factor (rhEGF)-triggered EGFR internalization promoted radioresistance. Here, we aimed to evaluate the effect of rhEGF on the skin protection of rectal and anal cancer patients receiving radiotherapy.MethodsOne hundred and ninety-three rectal and anal cancer patients who received radiotherapy were prospectively enrolled from January 2019 to December 2020. To perform self-controlled study, the left and right pelvic skin area (separated by midline) were randomly assigned to the rhEGF and control side. The association between radiation dermatitis and factors including rhEGF, the dose of radiotherapy and tumor distance from anal edge were analyzed.ResultsAmong 193 enrolled patients, 41 patients (21.2%) did not develop radiation dermatitis, and 152 patients (78.8%) suffered radiation dermatitis on at least one side of pelvic skin at the end of radiotherapy. For the effect on radiation dermatitis grade, rhEGF had improved effect on 6 (4.0%) patients, detrimental effect on 2 (1.3%) patients, and no effect on 144 (94.7%) patients. Whereas for the effect on radiation dermatitis area, rhEGF showed improved effect on the radiation dermatitis area of 46 (30.2%) patients, detrimental effect on 15 (9.9%) patients, and no effect on 91 (59.9%) patients. The radiation dermatitis area of rhEGF side was significantly smaller than that of control side (P= 0.0007).ConclusionsrhEGF is a skin protective reagent for rectal and anal cancer patients receiving radiotherapy.Trial registrationChinese Clinical Trial Registry identifier: ChiCTR1900020842; Date of registration: 20/01/2019.
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辐射引起的皮肤损伤：发病机理，治疗和管理。
DOI：
10.18632/aging.103932
发表时间：
2020-11-16
期刊：
Aging
影响因子：
--
作者：
Yang X;Ren H;Guo X;Hu C;Fu J
通讯作者：
Fu J
影响因子：
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作者：
Kong, Moonkyoo;Hong, Seong Eon
通讯作者：
Hong, Seong Eon
影响因子：
3.1
作者：
Lee, Sang-wook;Moon, Sue Young;Hong, Joon Pio
通讯作者：
Hong, Joon Pio
影响因子：
2.1
作者：
Hong JP;Lee SW;Song SY;Ahn SD;Shin SS;Choi EK;Kim JH
通讯作者：
Kim JH
影响因子：
2
作者：
Oh, Haejin;Seong, Jinsil;Song, Mihee
通讯作者：
Song, Mihee