Recombinant human epidermal growth factor treatment of radiation-induced severe oral mucositis in patients with head and neck malignancies.
Recombinant human epidermal growth factor treatment of radiation-induced severe oral mucositis in patients with head and neck malignancies.
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DOI：
10.1111/j.1365-2354.2008.00971.x
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发表时间：
2009-11
影响因子：
2.1
通讯作者：
Kim JH
中科院分区：
文献类型：
--
作者：
Hong JP;Lee SW;Song SY;Ahn SD;Shin SS;Choi EK;Kim JH
口腔和咽部粘膜炎是头颈部癌症患者放射治疗（RT）的主要剂量限制因素。因此，我们评估了人重组表皮生长因子（rhEGF）在头颈癌和淋巴瘤患者放疗（有或无联合化疗诱导的口腔粘膜炎）的伤口愈合效果。牙山医疗中心的患者接受了头颈部区域的确定性RT，伴或不伴联合化疗，并且发生了严重的口腔粘膜炎（高于放射治疗肿瘤组3级），每天两次局部使用rhEGF治疗7天。1周后进行口腔粘膜炎反应评价。在11名接受治疗的患者中，3名患有鼻咽癌，3名患有口咽癌，2名患有口腔癌，1名患有下咽癌，2名患有头颈部淋巴瘤。6例患者仅接受RT，5例患者同时接受放化疗。所有患者的口腔粘膜炎局部治疗后，与rhEGF的放射治疗肿瘤组等级显着下降（P = 0.0000）。这一发现表明，rhEGF是有效和安全的治疗放射性粘膜炎。需要进一步的研究来确定最佳剂量和分次方案。
Mucositis of the oral cavity and pharynx is a major dose-limiting factor in the application of radiotherapy (RT) to patients with head and neck cancer. Therefore, we evaluated the wound healing effect of human recombinant epidermal growth factor (rhEGF) in head and neck cancer and lymphoma patients with irradiation (with or without combined chemotherapy-induced oral mucositis). Patients at Asan Medical Center who had undergone definitive RT of the head and neck region with or without combined chemotherapy and who had developed severe oral mucositis (higher than the Radiation Therapy Oncology Group grade 3) were treated with topical rhEGF twice daily for 7 days. The evaluation of response with regard to oral mucositis was performed 1 week later. Of the 11 treated patients, three had nasopharyngeal carcinoma, three had carcinoma of the oropharynx, two had carcinoma of the oral cavity, one had carcinoma of the hypopharynx and two had lymphoma of the head and neck. Six patients received RT only, and five patients received concurrent chemoradiotherapy. All patients showed improvements in their oral mucositis after topical treatment with rhEGF in that the Radiation Therapy Oncology Group grade was significantly decreased (P = 0.0000). This finding suggests that rhEGF is effective and safe for the treatment of radiation-induced mucositis. Further studies are needed to determine the optimal dosage and fractionation schedule.
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DOI：
10.1097/00000421-199510000-00009
发表时间：
1995-10-01
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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