Advances in Escherichia coli Nissle 1917 as a customizable drug delivery system for disease treatment and diagnosis strategies.
Advances in Escherichia coli Nissle 1917 as a customizable drug delivery system for disease treatment and diagnosis strategies.
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大肠杆菌 Nissle 1917 作为疾病治疗和诊断策略的可定制药物输送系统的进展
DOI：
10.1016/j.mtbio.2023.100543
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发表时间：
2023-02
影响因子：
8.2
通讯作者：
Sun, Da
中科院分区：
文献类型：
--
作者：
Chen, Haojie;Lei, Pengyu;Ji, Hao;Yang, Qinsi;Peng, Bo;Ma, Jiahui;Fang, Yimeng;Qu, Linkai;Li, Hua;Wu, Wei;Jin, Libo;Sun, Da
随着对人体内细菌及其相关生态系统的深入和全面研究，基于细菌的药物递送系统已成为一种能够保留先天生物功能的新兴仿生平台。受益于其良好的生物相容性和作为生物载体的理想靶向能力，大肠杆菌Nissle 1917（ECN）一直专注于炎症性肠病和肿瘤的治疗策略。细菌载体的优点是它可以表达外源蛋白，同时也可以作为天然胶囊，通过其自身的定植影响缓慢释放药物。为了在消化道和肿瘤微环境等恶劣环境中生存，可以对ECN进行修饰或基因工程，以增强其功能和宿主适应性。采用ECN携带或表达对于准确诊断和治疗至关重要的药物。本文简要介绍了ECN的特性、ECN与炎症和肿瘤的关系以及利用表面修饰和基因工程修饰ECN作为疾病治疗的递送载体的策略。
With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain the innate biological functions. Benefiting from its good biocompatibility and ideal targeting ability as a biological carrier, Escherichia coli Nissle 1917 (ECN) has been focused on the treatment strategies of inflammatory bowel disease and tumor. The advantage of a bacterial carrier is that it can express exogenous protein while also acting as a natural capsule by releasing drug slowly as a result of its own colonization impact. In order to survive in harsh environments such as the digestive tract and tumor microenvironment, ECN can be modified or genetically engineered to enhance its function and host adaptability. The adoption of ECN carries or expresses drugs which are essential for accurate diagnosis and treatment. This review briefly describes the properties of ECN, the relationship between ECN and inflammation and tumor, and the strategy of using surface modification and genetic engineering to modify ECN as a delivery carrier for disease treatment.
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