Protein synthesis by platelets: historical and new perspectives.

Protein synthesis by platelets: historical and new perspectives.
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DOI:
10.1111/j.1538-7836.2008.03211.x
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发表时间:
2009-02
期刊:
Journal of thrombosis and haemostasis : JTH
影响因子:
--
通讯作者:
Zimmerman GA
Zimmerman GA
中科院分区:
其他
文献类型:
--
作者:
Weyrich AS;Schwertz H;Kraiss LW;Zimmerman GA

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20世纪60年代末,S等多位研究者独立证明了血小板具有合成蛋白质的能力。在接下来的30年里,研究以稳定的速度继续进行,一直持续到21世纪。总而言之,这些研究证实了血小板合成蛋白质,蛋白质合成模式随着细胞激活而改变。最近的研究已经表征了血小板合成蛋白质的机制,并表明蛋白质合成改变了血小板的表型和功能。在这里,我们按时间顺序回顾我们对血小板中蛋白质合成反应的理解,并讨论该领域在未来十年可能如何演变。
In the late 1960’s numerous investigators independently demonstrated that platelets are capable of synthesizing proteins. Studies continued at a steady pace over the next 30 years and into the 21st century. Collectively, these investigations confirmed that platelets synthesize proteins and that the pattern of protein synthesis changes in response to cellular activation. More recent studies have characterized the mechanisms by which platelets synthesize proteins and have shown that protein synthesis alters the phenotype and functions of platelets. Here, we chronologically review our increased understanding of protein synthetic responses in platelets and discuss how the field may evolve over the next decade.
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发表时间: 1968-01-01
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