Senescent cells: A therapeutic target for osteoporosis.
Senescent cells: A therapeutic target for osteoporosis.
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衰老细胞：骨质疏松症的治疗靶点
DOI：
10.1111/cpr.13323
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发表时间：
2022-12
影响因子：
8.5
通讯作者：
中科院分区：
文献类型：
--
作者：
骨质疏松症（Osteoporosis，OP）是一种以骨量丢失和骨微结构恶化为特征的常见疾病。OP可归因于多种因素，包括绝经（主要），衰老（主要）和药物的不良反应（次要）。最近，细胞衰老已被证明在维持细胞内稳态和器官功能方面具有至关重要的作用。本综述的目的是总结骨细胞衰老和衰老相关分泌表型（SASP）在OP中的作用的最新研究结果。对PubMed数据库进行了从成立到2022年7月的全面检索，了解骨细胞衰老在OP进展中的分子机制。我们描述了衰老的骨细胞和SASP的病理生理学，以及它们是如何对OP起作用的。我们还通过靶向细胞衰老途径为治疗OP提供了新的选择。细胞衰老在骨稳态中起着重要作用，基于不同类型的OP而变化。这些变化与致病因素、骨转换率和全身代谢有关。了解骨细胞和衰老之间的分子关系提供了可能的靶向衰老作为治疗OP的手段。骨是一种代谢活性组织，参与运动、支持和保护软组织、钙和磷酸盐储存以及骨髓窝藏的生理过程。骨是由经历连续重塑的各种类型的细胞构成的。骨代谢的维持包括成骨细胞的骨形成和破骨细胞的骨吸收。破骨细胞是终末分化的多核细胞，其来源于造血干细胞谱系的单核细胞（巨噬细胞）。间充质干细胞是成骨细胞和脂肪细胞的祖细胞。H型血管形成将骨髓中的骨生成与血管生成偶联并促进骨形成。骨细胞是包埋在骨基质细胞中的终末分化的成骨细胞。
Osteoporosis (OP) is a prevalent disorder characterized by the loss of bone mass and the deterioration of bone microarchitecture. OP is attributed to various factors, including menopause (primary), ageing (primary) and the adverse effects of medications (secondary). Recently, cellular senescence has been shown to have a crucial role in the maintenance of cellular homeostasis and organ function. The purpose of this review is to summarize recent findings regarding the roles of bone cellular senescence and senescence‐associated secretory phenotype (SASP) in OP. A comprehensive search of the PubMed database from inception to July 2022 was performed regarding the molecular mechanism of bone cell senescence in OP progression. We describe the pathophysiology of senescent bone cells and SASP, and how each contributes to OP. We also provide new options for treating OP by targeting cellular senescence pathways. Cellular senescence plays an important role in bone homeostasis, with variations based on the different types of OP. These variations are associated with pathogenic factors, bone turnover rate and systemic metabolism. Understanding the molecular relationship between bone cells and senescence provides for the possible targeting of senescence as a means by which to treat OP. Bone is a metabolically active tissue involved in physiological processes of locomotion, support and protection of soft tissues, calcium and phosphate storage, and harbouring of bone marrow. Bone is constituted by various types of cells undergoing continuous remodelling. The maintenance of bone metabolism includes bone formation by osteoblasts and resorption by osteoclasts. Osteoclasts are terminally differentiated multinucleated cells that are derived from mononuclear cells (macrophages) of the haematopoietic stem cell lineage. Mesenchymal stem cells are progenitors of osteoblasts and adipocytes. Type H vessel formation couples osteogenesis with angiogenesis in the bone marrow and promotes bone formation. Osteocytes are terminally differentiated osteoblasts embedded in bone matrix cells.
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影响因子：
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