Symposium 2 : The fatty acid transporters of skeletal muscle Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle
Symposium 2 : The fatty acid transporters of skeletal muscle Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle
复制标题
研讨会2：骨骼肌的脂肪酸转运蛋白人类骨骼肌质膜脂肪酸结合蛋白和其他脂质结合蛋白的研究
DOI：
--
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
B. Kiens
中科院分区：
文献类型：
--
作者：
C. Roepstorff;J. Helge;B. Vistisen;B. Kiens
第一个公认的脂肪酸转运蛋白是质膜脂肪酸结合蛋白（FABPpm）。后来证明这种蛋白质与天冬氨酸氨基转移酶的线粒体亚型相同。近年来，来自几种细胞类型的数据已经出现，表明FABPpm在长链饱和和不饱和脂肪酸的运输中起作用。在有限的人类骨骼肌研究中，已经证明膳食组成和运动训练可以影响FABPpm的含量。摄入富含脂肪的饮食诱导人骨骼肌中FABPpm蛋白含量增加，而在摄入富含碳水化合物的饮食期间观察到FABPpm蛋白含量减少。富脂饮食对胞质脂肪酸结合蛋白和脂肪酸转位酶/CD 36蛋白表达也有类似的影响。运动训练上调了骨骼肌中的FABPpm蛋白质含量，但仅限于男性受试者;在对不同训练状态的女性志愿者进行的横断面研究中，未观察到肌肉FABPpm含量存在显着差异，尽管肌肉FABPpm含量并不取决于未训练状态下的性别。男性在运动过程中对血浆长链脂肪酸的利用率高于女性，这可以解释运动训练对FABPpm的性别依赖性影响。FABPpm蛋白的功能和表达的调控机制仍有待阐明。
The first putative fatty acid transporter identified was plasma membrane fatty acid-binding protein (FABPpm). Later it was demonstrated that this protein is identical to the mitochondrial isoform of the enzyme aspartate aminotransferase. In recent years data from several cell types have emerged, indicating that FABPpm plays a role in the transport of long-chain saturated and unsaturated fatty acids. In the limited number of studies in human skeletal muscle it has been demonstrated that dietary composition and exercise training can influence the content of FABPpm. Ingestion of a fat-rich diet induces an increase in FABPpm protein content in human skeletal muscle in contrast to the decrease seen during consumption of a carbohydrate-rich diet. A similar effect of a fat-rich diet is also observed for cytosolic fatty acid-binding protein and fatty acid translocase/CD36 protein expression. Exercise training up regulates FABPpm protein content in skeletal muscle, but only in male subjects; no significant differences were observed in muscle FABPpm content in a cross-sectional study of female volunteers of varying training status, even though muscle FABPpm content did not depend on gender in the untrained state. A higher utilization of plasma long-chain fatty acids during exercise in males compared with females could explain the gender-dependent influence of exercise training on FABPpm. The mechanisms involved in the regulation of the function and expression of FABPpm protein remain to be clarified.
登录
查看更多内容
DOI：
10.1073/pnas.95.15.8625
发表时间：
1998-07-21
影响因子：
11.1
作者：
Hirsch, D;Stahl, A;Lodish, HF
通讯作者：
Lodish, HF
心脏巨囊泡中蛋白质介导的棕榈酸酯摄取和脂肪酸转运蛋白的表达。
影响因子：
6.5
作者：
Luiken,JJ;Turcotte,LP;Bonen,A
通讯作者：
Bonen,A
DOI：
10.1073/pnas.82.1.4
发表时间：
1985
影响因子：
11.1
作者：
W. Stremmel;G. Strohmeyer;F. Borchard;S. Kochwa;P. Berk
通讯作者：
W. Stremmel;G. Strohmeyer;F. Borchard;S. Kochwa;P. Berk
DOI：
10.1073/pnas.87.9.3484
发表时间：
1990-05-01
影响因子：
11.1
作者：
BERK, PD;WADA, H;THUNG, S
通讯作者：
THUNG, S
训练引起的 FABP(PM) 升高与收缩肌肉时棕榈酸酯的使用增加有关。
DOI：
10.1152/jappl.1999.87.1.285
发表时间：
1999
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Turcotte,LP;Swenberger,JR;Tucker,MZ;Yee,AJ
通讯作者：
Yee,AJ