Rapid Sensory Adaptation Redux: A Circuit Perspective.

Rapid Sensory Adaptation Redux: A Circuit Perspective.
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DOI:
10.1016/j.neuron.2016.09.046
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发表时间:
2016-10-19
期刊:
影响因子:
16.2
通讯作者:
Stanley GB
Stanley GB
中科院分区:
医学1区
文献类型:
--
作者:
Whitmire CJ;Stanley GB

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适应是生命的根本。所有的生物都在适应时间尺度,从进化到世代,从生命到每时每刻的相互作用。神经系统特别擅长于迅速适应变化,事实上,这可能是其组织和功能的基本原则之一。快速形式的感觉适应已经在广泛的生物体中的所有感觉模式中得到了很好的记录,但是我们对最终引起相应感知的适应性细胞机制没有全面的了解,部分原因是电路的复杂性。在这个角度来看,我们的目标是通过研究跨大脑区域和子区域以及跨特定细胞类型的差异适应,在神经回路的多个尺度上建立适应之间的联系,现代工具的爆炸刚刚开始启用。这项调查指出了该领域的一系列挑战,将功能观察与最终构成感知的神经回路的自适应特性联系起来。
Adaptation is fundamental to life. All organisms adapt over timescales that span from evolution to generations and lifetimes to moment-by-moment interactions. The nervous system is particularly adept at rapidly adapting to change, and this in fact may be one of its fundamental principles of organization and function. Rapid forms of sensory adaptation have been well-documented across all sensory modalities in a wide range of organisms, yet we do not have a comprehensive understanding of the adaptive cellular mechanisms that ultimately give rise to the corresponding percepts due in part to the complexity of the circuitry. In this Perspective, we aim to build links between adaptation at multiple scales of neural circuitry by investigating the differential adaptation across brain regions and sub-regions and across specific cell-types, for which the explosion of modern tools has just begun to enable. This investigation points to a set of challenges for the field to link functional observations to adaptive properties of the neural circuit that ultimately underlie percepts.
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