Development of novel drugs from marine surface associated microorganisms.
Development of novel drugs from marine surface associated microorganisms.
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DOI：
10.3390/md8030438
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发表时间：
2010-03-01
期刊：
影响因子：
5.4
通讯作者：
Egan S
中科院分区：
文献类型：
--
作者：
Penesyan A;Kjelleberg S;Egan S
虽然海洋覆盖了地球表面的70%以上，但海洋衍生的微生物天然产物在很大程度上尚未开发。海洋环境是许多独特微生物的栖息地，它们产生生物活性化合物（“生物活性物质”）以适应特定的环境条件。例如，海洋表面相关微生物已被证明是新型生物活性物质的丰富来源，因为需要进化能够保护生产者免受海洋真核生物表面上微生物之间存在的激烈竞争的化感物质。化学驱动的相互作用对于在微生物和它们的真核宿主之间建立交叉关系也是重要的，其中产生抗微生物化合物（“抗微生物剂”）的生物体可以保护宿主表面免受过度定殖，以换取营养丰富的环境。与生物活性物质的发现一样，海洋微生物生物活性物质的检测和表征进展受到许多障碍的限制，例如不合适的培养条件、费力的纯化过程和缺乏去复制。然而，由于改进的微生物培养技术、微生物（Meta）基因组分析和用于结构解析的新型灵敏分析工具，这些限制中的许多限制现在正在被克服。在这里，我们将讨论这些技术进步，以及对微生物和化学生态学的更好理解，将不可避免地转化为未来海洋微生物来源的新药发现和开发的增加。
While the oceans cover more than 70% of the Earth’s surface, marine derived microbial natural products have been largely unexplored. The marine environment is a habitat for many unique microorganisms, which produce biologically active compounds (“bioactives”) to adapt to particular environmental conditions. For example, marine surface associated microorganisms have proven to be a rich source for novel bioactives because of the necessity to evolve allelochemicals capable of protecting the producer from the fierce competition that exists between microorganisms on the surfaces of marine eukaryotes. Chemically driven interactions are also important for the establishment of cross-relationships between microbes and their eukaryotic hosts, in which organisms producing antimicrobial compounds (“antimicrobials”), may protect the host surface against over colonisation in return for a nutrient rich environment. As is the case for bioactive discovery in general, progress in the detection and characterization of marine microbial bioactives has been limited by a number of obstacles, such as unsuitable culture conditions, laborious purification processes, and a lack of de-replication. However many of these limitations are now being overcome due to improved microbial cultivation techniques, microbial (meta-) genomic analysis and novel sensitive analytical tools for structural elucidation. Here we discuss how these technical advances, together with a better understanding of microbial and chemical ecology, will inevitably translate into an increase in the discovery and development of novel drugs from marine microbial sources in the future.
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影响因子：
4.1
作者：
Burgess, JG;Jordan, EM;Boyd, KG
通讯作者：
Boyd, KG
影响因子：
15
作者：
Brady, SF;Clardy, J
通讯作者：
Clardy, J
影响因子：
5.2
作者：
Boonlarppradab, Chollaratt;Kauffman, Christopher A.;Jensen, Paul R.;Fenical, William
通讯作者：
Fenical, William
影响因子：
4
作者：
Bills, G. F.;Platas, G.;Pelaez, F.
通讯作者：
Pelaez, F.
影响因子：
4.4
作者：
Brady, SF;Chao, CJ;Clardy, J
通讯作者：
Clardy, J