Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis.
Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis.
复制标题
DOI：
10.3390/pathogens9110904
复制
发表时间：
2020-10-29
期刊：
影响因子：
--
通讯作者：
Jain P
中科院分区：
文献类型：
--
作者：
Dykie A;Wijesinghe T;Rabson AB;Madugula K;Farinas C;Wilson S;Abraham D;Jain P
人类T细胞白血病/淋巴瘤病毒1型（HTLV-1）感染与多种临床综合征相关，包括与粪类圆线虫（Strongyloides stercoralis）共感染，粪类圆线虫是一种肠道寄生线虫，是人类类圆线虫病的主要病因。有趣的是，HTLV-1流行区与S.粪感染，使这些社区最适合阐明共同感染的发病机制及其临床意义。HTLV-1与S.在许多已发表的患者病例和病例系列中观察到粪球菌已有数十年;然而，这种合并感染的影响仍然难以捉摸。到目前为止，数据表明，S。与单独的HTLV-1感染相比，Stercoralis增加了合并感染HTLV-1的患者中的前病毒负荷。此外，与HTLV-1的共感染与将免疫应答从Th 2转移到Th 1相关，影响免疫系统解决蠕虫感染的能力。因此，尽管存在这种众所周知的关联，但需要进一步研究以充分阐明每种病原体对合并感染患者的疾病表现的影响。本文综述了HTLV-1患者对S.粪感染，以及类圆线虫病对HTLV-1发病机制的影响。此外，它还提供了关于HTLV-1与寄生虫共感染的流行病学和病理学的现有临床报告汇编，以及来自机制研究的数据，表明可能的免疫致病机制。此外，还强调了未来潜在研究的具体领域，以促进对这两种病原体之间复杂相互作用的理解。
Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated with various clinical syndromes including co-infection with Strongyloides stercoralis, which is an intestinal parasitic nematode and the leading cause of strongyloidiasis in humans. Interestingly, HTLV-1 endemic areas coincide with regions citing high prevalence of S. stercoralis infection, making these communities optimal for elucidating the pathogenesis of co-infection and its clinical significance. HTLV-1 co-infection with S. stercoralis has been observed for decades in a number of published patient cases and case series; however, the implications of this co-infection remain elusive. Thus far, data suggest that S. stercoralis increases proviral load in patients co-infected with HTLV-1 compared to HTLV-1 infection alone. Furthermore, co-infection with HTLV-1 has been associated with shifting the immune response from Th2 to Th1, affecting the ability of the immune system to address the helminth infection. Thus, despite this well-known association, further research is required to fully elucidate the impact of each pathogen on disease manifestations in co-infected patients. This review provides an analytical view of studies that have evaluated the variation within HTLV-1 patients in susceptibility to S. stercoralis infection, as well as the effects of strongyloidiasis on HTLV-1 pathogenesis. Further, it provides a compilation of available clinical reports on the epidemiology and pathology of HTLV-1 with parasitic co-infection as well as data from mechanistic studies suggesting possible immunopathogenic mechanisms. Furthermore, specific areas of potential future research have been highlighted to facilitate advancing understanding of the complex interactions between these two pathogens.
登录
查看更多内容
影响因子：
3.3
作者：
Blaizot, Romain;Simon, Stephane;Demar, Magalie
通讯作者：
Demar, Magalie
影响因子：
3.3
作者：
Banerjee P;Crawford L;Samuelson E;Feuer G
通讯作者：
Feuer G
影响因子：
3.7
作者：
Akkina R
通讯作者：
Akkina R
影响因子：
0.9
作者：
Barros, Nicolas;Woll, Fernando;Montes, Martin
通讯作者：
Montes, Martin
影响因子：
1.5
作者：
DETHE, G;BOMFORD, R
通讯作者：
BOMFORD, R