Using Network Pharmacology to Explore the Mechanism of Peach Kernel-Safflower in the Treatment of Diabetic Nephropathy.
Using Network Pharmacology to Explore the Mechanism of Peach Kernel-Safflower in the Treatment of Diabetic Nephropathy.
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DOI：
10.1155/2021/6642584
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发表时间：
2021
影响因子：
--
通讯作者：
Zhao T
中科院分区：
文献类型：
--
作者：
Han J;Wang X;Hou J;Liu Y;Liu P;Zhao T
采用网络药理学方法研究桃仁红花治疗糖尿病肾病的作用机制。 应用网络药理学方法，在SymMap和TCMSP数据库中筛选桃仁红花有效成分。然后在ETCM、SEA和SymMap数据库中筛选潜在靶标以构建化合物-靶标网络。随后在OMIM、Gene和GeneCards数据库中筛选DN靶标。在STRING数据库中选择药物和疾病的共同靶标进行分析，并将结果导入Cytoscape 3.8.0构建蛋白质-蛋白质相互作用网络。接下来，进行GO和KEGG富集分析。最后，薛定谔分子对接验证了结果的可靠性。 通过筛选共得到23个有效化合物和794个潜在靶点。结果表明，桃仁红花的主要有效成分为槲皮素和木犀草素。此外，5个关键靶点（VEGFA、IL 6、TNF、AKT 1和TP 53）、AGE-T、流体剪切应力和动脉粥样硬化、IL-17和HIF-1信号通路可能参与桃仁-红花治疗DN。 本研究体现了桃仁-红花治疗糖尿病肾病的多组分、多靶点、多途径的复杂网络关系，为进一步研究其作用机制提供了基础。
The mechanism of peach kernel-safflower in treating diabetic nephropathy (DN) was investigated using network pharmacology. Network pharmacology methodology was applied to screen the effective compounds of peach kernel-safflower in the SymMap and TCMSP databases. Potential targets were then screened in the ETCM, SEA, and SymMap databases to construct a compound-target network. This was followed by screening of DN targets in OMIM, Gene, and GeneCards databases. The common targets of drugs and diseases were selected for analysis in the STRING database, and the results were imported into Cytoscape 3.8.0 to construct a protein-protein interaction network. Next, GO and KEGG enrichment analyses were performed. Finally, Schrödinger molecular docking verified the reliability of the results. A total of 23 effective compounds and 794 potential targets resulted from our screening process. Quercetin and luteolin were identified as the main effective ingredients in peach kernel-safflower. Furthermore, five key targets (VEGFA, IL6, TNF, AKT1, and TP53), AGE-RAGE, fluid shear stress and atherosclerosis, IL-17, and HIF-1 signaling pathways may be involved in the treatment of DN using peach kernel-safflower. This study embodies the complex network relationship of multicomponents, multitargets, and multipathways of peach kernel-safflower to treat DN and provides a basis for further research on its mechanism.
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影响因子：
6.1
作者：
Li, Xiyue;Yang, Sisi;Hao, Chuanming
通讯作者：
Hao, Chuanming
DOI：
10.2741/s135
发表时间：
2011-01-01
期刊：
Frontiers in bioscience (Scholar edition)
影响因子：
--
作者：
Heljic, Mediha;Brazil, Derek P
通讯作者：
Brazil, Derek P
影响因子：
4.3
作者：
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通讯作者：
Wu H
影响因子：
7.5
作者：
Cui, Yan;Shi, Yan;Liu, Yun
通讯作者：
Liu, Yun
口服低剂量槲皮素对高胆固醇小鼠糖尿病性肾病的保护作用。
影响因子：
4
作者：
Gomes IB;Porto ML;Santos MC;Campagnaro BP;Gava AL;Meyrelles SS;Pereira TM;Vasquez EC
通讯作者：
Vasquez EC