Immune cell-mediated venous thrombus resolution.
Immune cell-mediated venous thrombus resolution.
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DOI：
10.1016/j.rpth.2023.102268
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发表时间：
2023-11
影响因子：
4.6
通讯作者：
Obi, Andrea
中科院分区：
文献类型：
--
作者：
Henke, Peter K.;Nicklas, John M.;Obi, Andrea
在本文中，我们回顾了目前控制实验性深静脉血栓（DVT）解决的过程。由于样本有限，人类DVT在分子和细胞水平上如何分解尚不清楚。在实验中，血栓的溶解类似于伤口愈合，早期是中性粒细胞介导的作用，随后是单核细胞/巨噬细胞介导的事件，包括新生血管、纤维蛋白溶解和最终的胶原蛋白替代。潜在的治疗靶点被描述，并且与位点导向的方法耦合以减轻脱靶效应是长期目标。同样，辅助药物加速DVT解决的时机也是一个刚刚开始被考虑的领域。在这一领域需要进行许多关键性的研究。深静脉血栓如何溶解是一个复杂且未被充分研究的过程。免疫细胞以协调和时间依赖的方式介导解决过程。纤维蛋白溶解、新生血管形成和收缩都是可能改变的过程。在不抗凝的情况下，需要靶向治疗来促进静脉血栓的溶解。
Herein, we review the current processes that govern experimental deep vein thrombus (DVT) resolution. How the human DVT resolves at the molecular and cellular level is not well known due to limited specimen availability. Experimentally, the thrombus resolution resembles wound healing, with early neutrophil-mediated actions followed by monocyte/macrophage–mediated events, including neovascularization, fibrinolysis, and eventually collagen replacement. Potential therapeutic targets are described, and coupling with site-directed approaches to mitigate off-target effects is the long-term goal. Similarly, timing of adjunctive agents to accelerate DVT resolution is an area that is only starting to be considered. There is much critical research that is needed in this area. How a deep vein thrombus resolves is a complex and understudied process. Immune cells mediate the resolution process in a coordinated and time-dependent fashion. Fibrinolysis, neovascularization, and retraction are all potentially modifiable processes. Targeted therapies to promote venous thrombus resolution without anticoagulation are needed.
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