The -7351C/T polymorphism in the TPA gene and ischemic stroke risk: a meta-analysis.
The -7351C/T polymorphism in the TPA gene and ischemic stroke risk: a meta-analysis.
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TPA 基因中的 -7351C/T 多态性与缺血性中风风险：荟萃分析。
DOI：
10.1371/journal.pone.0053558
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Sheng W
中科院分区：
文献类型：
--
作者：
Sun X;Lai R;Li J;Luo M;Wang Y;Sheng W
许多研究评估了组织型纤溶酶原激活剂（TPA）基因多态性与缺血性卒中的关系，但结果相互矛盾。本研究旨在通过Meta分析探讨TPA-7351 C/T SNP在缺血性脑卒中易感性中的作用。检索PubMed、MEDLINE、EMBASE、中国生物医学数据库和万方数据库，直至2012年8月。确定严格的选择标准和排除标准，并使用比值比（OR）和95%置信区间（CI）评估关联的强度。使用急性治疗标准中的试验10172（吐司）确定卒中亚型。使用STATA12.0软件进行统计分析。荟萃分析共纳入了7项病例对照研究中的2,299例缺血性卒中病例和1,948例对照。TPA基因-7351C/T多态性与缺血性卒中在所有比较模型（TT+CT与CC、TT与CT+CC和T与C）中均观察到显著关联。在按种族进行的亚组分析中，在东亚人群中，TT纯合子携带者与C等位基因携带者相比，缺血性卒中的风险增加142%（TT与CT+CC：OR = 2.42，95% CI = 1.07-5.48），但在南亚人群和高加索人群中没有增加，在东亚人群（OR = 1.33，95% CI = 1.05-1.68）和高加索人群（OR = 1.16，95% CI = 1.02-1.31）中，T与C等位基因携带者相比，风险显著增加。 在三项高加索人研究中，进一步对卒中亚型进行分层显示-7351C/T多态性与大动脉粥样硬化（LAA）相关，但与小血管闭塞（SVO）和动脉栓塞（CE）无关。TPA基因-7351C/T多态性可能是缺血性脑卒中的危险因素，尤其是在东亚人群中，而在南亚人群中不存在; TPA基因-7351C/T多态性可能在白种人LAA的发病中起作用，但在SVO和CE中不起作用。
A number of studies assessed the association of tissue plasminogen activator(TPA) gene polymorphisms with ischemic stroke, but the results were contradictory. We aimed to explore the role of TPA -7351C/T SNP in the susceptibility to ischemic stroke through a meta-analysis. The PubMed, MEDLINE, EMBASE, China Biological Medicine Database and WANFANG DATA databases were searched until August 2012. The strict selection criteria and exclusion criteria were determined, and odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Stroke subtype was determined using Trial of Org 10172 in Acute Treatment criteria (TOAST). Statistical analyses were performed using the STATA12.0 software. A total of 2,299 ischemic stroke cases and 1,948 controls in seven case-control studies were included in the meta-analysis. Significant association between -7351C/T polymorphism in the TPA gene and ischemic stroke was observed in all comparison models (TT+CT versus CC, TT versus CT+CC and T versus C). In the subgroup analysis by ethnicity, TT homozygote carriers had a 142% increased risk of ischemic stroke compared with the C allele carriers among East-Asians (TT versus CT+CC: OR = 2.42, 95% CI = 1.07–5.48), but not in South-Asians and Caucasians, and significantly increased risks were found for T versus C among both East-Asians (OR = 1.33, 95% CI = 1.05–1.68) and Caucasians(OR = 1.16, 95% CI = 1.02–1.31). Further stratification for stroke subtype in three Caucasian studies showed the association between -7351C/T polymorphism and Large-artery atherosclerosis (LAA), but not Small-vessel occlusion (SVO) and Cardioembolism (CE). This meta-analysis suggested that the -7351C/T polymorphism in TPA gene would be a risk factor for ischemic stroke, especially among East-Asians compared with Caucasians, but not in South-Asians, and it may play a role in the pathogenesis of LAA in Caucasians, but not in SVO and CE.
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DOI：
10.1016/j.jstrokecerebrovasdis.2007.03.002
发表时间：
2007-07-01
期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子：
--
作者：
Attia, John;Thakkinstian, Ammarin;Levi, Christopher
通讯作者：
Levi, Christopher
影响因子：
8.3
作者：
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影响因子：
6.7
作者：
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Jern, C
影响因子：
8.3
作者：
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作者：
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