Evaluation of the Expression of Amine Oxidase Proteins in Breast Cancer.
Evaluation of the Expression of Amine Oxidase Proteins in Breast Cancer.
复制标题
乳腺癌中胺氧化酶蛋白表达情况的评估
DOI：
10.3390/ijms18122775
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发表时间：
2017-12-20
影响因子：
5.6
通讯作者：
Koo JS
中科院分区：
文献类型：
--
作者：
Sun WY;Choi J;Cha YJ;Koo JS
我们的目的是评估乳腺癌中胺氧化酶蛋白的表达及其临床意义。我们对胺氧化酶蛋白（LOX、赖氨酸氧化酶、AOC3、胺氧化酶、MAOA、单胺氧化酶A、MAOB、单胺氧化酶B）进行免疫组化染色。根据雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2 （HER-2）等激素受体及Ki-67免疫组化染色，将乳腺癌分为腔内A型、腔内B型、HER-2型和三阴性乳腺癌（TNBC） 4种分子亚型。Luminal A 380例（49.4%），Luminal B 224例（29.1%），HER-2 68例（8.8%），TNBC 98例（12.7%）。基质AOC3、MAO-A和MAO-B的表达因分子亚型而异。间质AOC3在管腔B和HER-2型中高表达，MAO-A在管腔A和管腔B中高表达（p < 0.001）。MAO-B在TNBC中的表达高于其他亚型（p = 0.020）。LOX阳性与高组织学分级（p < 0.001）和高Ki-67标记指数（LI） （p = 0.009）相关，间质AOC3阳性与高组织学分级（p = 0.001）、高Ki-67标记指数（p < 0.001）和HER-2阳性（p = 0.002）相关。MAO-A阳性与组织学分级低（p < 0.001）、ER阳性、PR阳性（p < 0.001）、Ki-67 LI低（p < 0.001）相关。单因素分析中，HER-2型患者MAO-A阳性与短期无病生存期相关（p = 0.013）， AOC3阴性与er阳性乳腺癌、pr阳性乳腺癌、HER-2阴性乳腺癌和淋巴结转移患者的短期无病生存期和总生存期相关。综上所述，胺氧化酶蛋白的表达取决于乳腺癌的分子亚型。间质AOC3在管腔B和HER-2型中高表达，MAO-A在管腔A和管腔B中高表达。
We aimed to evaluate the expression of amine oxidase proteins in breast cancer and their clinical implications. We performed immunohistochemical staining of amine oxidase proteins (LOX, lysyl oxidase, AOC3, amine oxidase, MAOA, monoamine oxidase A, MAOB, monoamine oxidase B). Based on their hormone receptors, such as estrogen receptor (ER) and progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 immunohistochemical staining, breast cancer was divided into four molecular subtypes: luminal A, luminal B, HER-2 type, and triple-negative breast cancer (TNBC). Luminal A was observed in 380 cases (49.4%), luminal B in 224 (29.1%), HER-2 type in 68 (8.8%), and TNBC in 98 (12.7%). Stromal AOC3, MAO-A, and MAO-B expression varied according to molecular subtypes. Stromal AOC3 expression was high in luminal B and HER-2 type and MAO-A expression was high in luminal A and luminal B (p < 0.001). MAO-B expression was higher in TNBC than in other subtypes (p = 0.020). LOX positivity was associated with high histological grade (p < 0.001) and high Ki-67 labeling index (LI) (p = 0.009), and stromal AOC3 positivity was associated with high histological grade (p = 0.001), high Ki-67 LI (p < 0.001), and HER-2 positivity (p = 0.002). MAO-A positivity was related to low histological grade (p < 0.001), ER positivity, PR positivity (p < 0.001), and low Ki-67 LI (p < 0.001). In univariate analysis, MAO-A positivity was related to short disease-free survival in HER-2 type (p = 0.013), AOC3 negativity was related to short disease-free survival and overall survival in ER-positive breast cancer, PR-positive breast cancer, HER-2-negative breast cancer, and lymph node metastasis. In conclusion, the expression of amine oxidase proteins varies depending on the molecular subtype of breast cancer. Stromal AOC3 expression was high in luminal B and HER-2 type, and MAO-A expression was high in luminal A and luminal B.
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影响因子：
5.8
作者：
LIZCANO, JM;ESCRICH, E;UNZETA, M
通讯作者：
UNZETA, M
影响因子：
--
作者：
Hanley CJ;Noble F;Ward M;Bullock M;Drifka C;Mellone M;Manousopoulou A;Johnston HE;Hayden A;Thirdborough S;Liu Y;Smith DM;Mellows T;Kao WJ;Garbis SD;Mirnezami A;Underwood TJ;Eliceiri KW;Thomas GJ
通讯作者：
Thomas GJ
影响因子：
3.8
作者：
Chen, Li-Ching;Tu, Shih-Hsin;Ho, Yuan-Soon
通讯作者：
Ho, Yuan-Soon
DOI：
10.18632/aging.101127
发表时间：
2016-12-15
期刊：
Aging
影响因子：
--
作者：
Mellone M;Hanley CJ;Thirdborough S;Mellows T;Garcia E;Woo J;Tod J;Frampton S;Jenei V;Moutasim KA;Kabir TD;Brennan PA;Venturi G;Ford K;Herranz N;Lim KP;Clarke J;Lambert DW;Prime SS;Underwood TJ;Vijayanand P;Eliceiri KW;Woelk C;King EV;Gil J;Ottensmeier CH;Thomas GJ
通讯作者：
Thomas GJ
影响因子：
4.2
作者：
Lee HT;Choi MR;Doh MS;Jung KH;Chai YG
通讯作者：
Chai YG