NK Cells in HIV-1 Infection: From Basic Science to Vaccine Strategies.
NK Cells in HIV-1 Infection: From Basic Science to Vaccine Strategies.
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DOI：
10.3389/fimmu.2018.02290
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发表时间：
2018
影响因子：
7.3
通讯作者：
Zapata W
中科院分区：
文献类型：
--
作者：
Flórez-Álvarez L;Hernandez JC;Zapata W
NK细胞在对抗HIV感染的免疫反应中起着关键作用。这些细胞可以通过作用于树突状细胞、T细胞、B细胞，甚至是上皮细胞，破坏受感染的细胞，并有助于产生足够和强大的适应性免疫反应。NK细胞活性的增强反映为更高的细胞毒能力、干扰素-γ和趋化因子(CCl_3、CCl_4和CCl_5)的产生，这与对艾滋病毒感染的抵抗和延缓艾滋病的进展有关，表明了这些细胞在抗病毒反应中的重要性。最近，具有适应性特征的NK细胞亚群被描述为与较低的HIV病毒血症和感染控制有关。这些证据，再加上基于提高NK细胞活性的疫苗试验所显示的某种程度的保护，表明这些细胞可以成为新的治疗和疫苗策略的可行选择，以克服传统疫苗接种方法可能对这种病毒造成的限制。本综述重点介绍了NK细胞在HIV免疫应答中的作用，包括与这些细胞相关的所有效应机制；此外，还将指出在HIV感染过程中的表型、功能和频率改变，强调基于NK细胞效应功能的疫苗开发机会。
NK cells play a key role in immune response against HIV infection. These cells can destroy infected cells and contribute to adequate and strong adaptive immune responses, by acting on dendritic, T, B, and even epithelial cells. Increased NK cell activity reflected by higher cytotoxic capacity, IFN-γ and chemokines (CCL3, CCL4, and CCL5) production, has been associated with resistance to HIV infection and delayed AIDS progression, demonstrating the importance of these cells in the antiviral response. Recently, a subpopulation of NK cells with adaptive characteristics has been described and associated with lower HIV viremia and control of infection. These evidences, together with some degree of protection shown in vaccine trials based on boosting NK cell activity, suggest that these cells can be a feasible option for new treatment and vaccination strategies to overcome limitations that, classical vaccination approaches, might have for this virus. This review is focus on the NK cells role during the immune response against HIV, including all the effector mechanisms associated to these cells; in addition, changes including phenotypic, functional and frequency modifications during HIV infection will be pointed, highlighting opportunities to vaccine development based in NK cells effector functions.
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
5.5
作者：
Cummings, Jean-Saville;Moreno-Nieves, Uriel Y.;Scott-Algara, Daniel
通讯作者：
Scott-Algara, Daniel
统一依赖MHC的天然杀手细胞教育的概念。
影响因子：
16.8
作者：
Elliott JM;Yokoyama WM
通讯作者：
Yokoyama WM
DOI：
10.1097/qad.0b013e32833424c8
发表时间：
2010-01-16
期刊：
AIDS (London, England)
影响因子：
--
作者：
Anderson DJ;Politch JA;Nadolski AM;Blaskewicz CD;Pudney J;Mayer KH
通讯作者：
Mayer KH
影响因子：
14.2
作者：
Campbell, Kerry S.;Hasegawa, Jun
通讯作者：
Hasegawa, Jun