Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure.
Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure.
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DOI：
10.1007/s00210-011-0622-1
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发表时间：
2011-05
影响因子：
3.6
通讯作者：
Watts, Stephanie W.
中科院分区：
文献类型：
--
作者：
Davis, Robert Patrick;Elizabeth Linder, A.;Watts, Stephanie W.
5-羟色胺（5-hydroxytryptamine; 5-HT）是离体血管的有效收缩剂。然而，最近的研究表明，慢性5-HT输注导致大鼠血压长期下降。这一发现强调了进一步研究5-HT在心血管系统中的必要性。我们测试了一个假设，即功能性5-羟色胺转运蛋白（SERT）是至关重要的，使5-HT诱导的血压下降。在雄性和雌性大鼠中进行实验，以确定性别是否显著影响5-HT降低血压的能力，并确定SERT依赖性在雄性大鼠与雌性大鼠中是否不同。5-HT（25 μg/kg/min; s.c.）向雄性和雌性SERT野生型（WT）和SERT敲除（KO）大鼠输注7天。通过无线电遥测监测平均动脉压（MAP）和心率。与雄性SERT KO大鼠（−10±2 mmHg）相比，5-HT在雄性SERT WT大鼠（−20±1 mmHg）中产生了显著更大的MAP下降（最低点）。同样，与SERT KO雌性大鼠（−15±0.4 mmHg）相比，5-HT也使SERT WT雌性大鼠（−19±1 mmHg）的MAP（最低点）显著下降。虽然缺乏功能性SERT蛋白并不能阻止5-HT诱导的血压下降，但它确实降低了5-HT降低雄性和雌性SERT大鼠血压的能力，这表明SERT在产生5-HT诱导的血压下降中具有潜在的重要作用。
Serotonin (5-hydroxytryptamine; 5-HT) is a potent constrictor of isolated blood vessels. However, recent studies demonstrate that chronic 5-HT infusion results in a prolonged fall in blood pressure in the rat. This finding highlights the need for further study of 5-HT in the cardiovascular system. We tested the hypothesis that a functional serotonin transporter (SERT) is critical to enabling a 5-HT-induced fall in blood pressure. Experiments were performed in male and female rats to determine whether gender significantly affected the ability of 5-HT to lower blood pressure and to determine whether SERT dependence was different in male vs. female rats. 5-HT (25 μg/kg/min; s.c.) was infused for 7 days to male and female, SERT wild-type (WT) and SERT knockout (KO) rats. Mean arterial pressure (MAP) and heart rate were monitored via radiotelemetry. 5-HT produced a significantly greater fall in MAP (at the nadir) in the male SERT WT rat (−20±1 mmHg) compared to the male SERT KO rat (−10±2 mmHg). Similarly, 5-HT also produced a significantly greater fall in MAP (at the nadir) in the female SERT WT rat (−19±1 mmHg) compared to the female SERT KO rat (−15±0.4 mmHg). While the lack of a functional SERT protein did not prevent a 5-HT-induced fall in blood pressure, it did reduce the ability of 5-HT to lower blood pressure in the male and female SERT rat, suggesting a potentially important role for SERT in producing a 5-HT-induced fall in blood pressure.
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影响因子：
4.7
作者：
Brenner, B.;Harney, J. T.;Kilic, F.
通讯作者：
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影响因子：
3.4
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Clippen, E.
DOI：
10.1073/pnas.0610964104
发表时间：
2007-05-08
影响因子：
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作者：
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