Extracellular matrix elasticity and topography: material-based cues that affect cell function via conserved mechanisms.
Extracellular matrix elasticity and topography: material-based cues that affect cell function via conserved mechanisms.
复制标题
DOI：
10.1002/jbm.a.35254
复制
发表时间：
2015-03
影响因子：
4.9
通讯作者：
Putnam, Andrew J.
中科院分区：
文献类型：
--
作者：
Janson, Isaac A.;Putnam, Andrew J.
化学、机械和地形的细胞外基质（ECM）线索对细胞行为的影响已被广泛研究。这些ECM信号改变细胞粘附、细胞形状和细胞迁移，并激活信号转导通路，影响基因表达、增殖和分化。特别是ECM的弹性和地形，已经成为备受关注的材料特性，基于强有力的证据，这些物理线索可以部分地决定干细胞的分化。细胞产生拉力来拉动它们的粘附接触，这些牵引力似乎是细胞对弹性和地形的反应的共同因素。这篇综述的重点是最近发表的将ECM地形和力学及其对分化和其他细胞行为的影响联系起来的工作，我们还强调了受地形提示的细胞共享的（或可能）机械转导的典型信号通路。最后，我们简要讨论了这些共性对细胞治疗和生物材料设计的潜在影响。
Chemical, mechanical, and topographic extracellular matrix (ECM) cues have been extensively studied for their influence on cell behavior. These ECM cues alter cell adhesion, cell shape, and cell migration, and activate signal transduction pathways to influence gene expression, proliferation, and differentiation. ECM elasticity and topography, in particular, have emerged as material properties of intense focus based on strong evidence these physical cue can partially dictate stem cell differentiation. Cells generate forces to pull on their adhesive contacts, and these tractional forces appear to be a common element of cells’ responses to both elasticity and topography. This review focuses on recently published work that links ECM topography and mechanics and their influence on differentiation and other cell behaviors, We also highlight signaling pathways typically implicated in mechanotransduction that are (or may be) shared by cells subjected to topographic cues. Finally, we conclude with a brief discussion of the potential implications of these commonalities for cell based therapies and biomaterial design.
登录
查看更多内容
影响因子：
64.5
作者：
Choquet, D;Felsenfeld, DP;Sheetz, MP
通讯作者：
Sheetz, MP
影响因子：
17.1
作者：
Chen W;Villa-Diaz LG;Sun Y;Weng S;Kim JK;Lam RH;Han L;Fan R;Krebsbach PH;Fu J
通讯作者：
Fu J
影响因子：
2.9
作者：
Arnold, M;Cavalcanti-Adam, EA;Spatz, JP
通讯作者：
Spatz, JP
影响因子：
14
作者：
Barker, Thomas H.
通讯作者：
Barker, Thomas H.
影响因子：
14
作者：
Charest, JL;Eliason, MT;King, WP
通讯作者：
King, WP