Lipopolysaccharide Detection across the Kingdoms of Life.
Lipopolysaccharide Detection across the Kingdoms of Life.
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DOI：
10.1016/j.it.2017.05.001
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发表时间：
2017-10
影响因子：
16.8
通讯作者：
Kagan JC
中科院分区：
文献类型：
--
作者：
Kagan JC
Studies in recent years have uncovered a diverse set of eukaryotic receptors that recognize lipopolysaccharide (LPS), the major outer-membrane component of gram-negative bacteria. Indeed, Toll-like Receptors, G-protein coupled receptors, Integrins, Receptor-like kinases, and caspases have emerged as important LPS-interacting proteins. In this Review, the mammalian receptors that detect LPS are described. I highlight how no host protein is involved in all LPS responses, but a single lipid (phosphatidylinositol 4,5-bisphosphate) regulates many LPS responses, including endocytosis, phagocytosis, inflammation and pyroptosis. I further describe LPS response systems that operate specifically in plants, and discuss potentially new LPS response systems that await discovery. This diversity of receptors for a single microbial product underscores the importance of host-microbe interactions in multiple kingdoms of life.
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影响因子：
4.8
作者：
Chiang, Chih-Yuan;Veckman, Ville;David, Michael
通讯作者：
David, Michael
影响因子：
7.3
作者：
Billings EA;Lee CS;Owen KA;D'Souza RS;Ravichandran KS;Casanova JE
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4.4
作者：
Ariki, Shigeru;Takahara, Shusaku;Kawabata, Shun-ichiro
通讯作者：
Kawabata, Shun-ichiro
DOI：
10.1126/science.1240988
发表时间：
2013-09-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hagar JA;Powell DA;Aachoui Y;Ernst RK;Miao EA
通讯作者：
Miao EA
影响因子：
64.5
作者：
Bonham KS;Orzalli MH;Hayashi K;Wolf AI;Glanemann C;Weninger W;Iwasaki A;Knipe DM;Kagan JC
通讯作者：
Kagan JC