Mechanophysiological analysis of anorectal function using simulated feces in human subjects.
Mechanophysiological analysis of anorectal function using simulated feces in human subjects.
复制标题
使用模拟人类粪便对肛门直肠功能进行机械生理学分析
DOI：
10.1016/j.jare.2020.07.002
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发表时间：
2021-03
影响因子：
10.7
通讯作者：
Gregersen H
中科院分区：
文献类型：
--
作者：
Sun D;Liao D;Chen SC;Wong C;Wah Leung W;Futaba K;Mak T;Ng S;Gregersen H
排便是一个复杂的过程，很难研究和分析。在这里，我们提出了新的分析工具来计算人类受试者在模拟粪便排出过程中的摩擦力和张力。这个12厘米长的仿生装置包含压力传感器、用于测量方向和弯曲的运动处理器单元，以及用于测量横截面积的阻抗环。8名正常受试者进行仿生排便。计算了装置的弯曲角度、装置与周围组织之间的摩擦力以及拉伸张力。在排气过程中，弯曲角度和压力发生了变化，最大压力记录在尾部。每个受试者的平均周向张力、纵向张力和摩擦力与前后压差相关（r >.7, p < 0.005）。尾部排出前的周向张力、纵向张力和摩擦力峰值均明显高于前方进入肛管时（F = 164.7, p < 0.005; F = 152.1, p < 0.005; F = 71.4, p < 0.005）。本研究表明，Fecobionics在生理条件下获得了可靠的数据。机械特征，如摩擦力和拉伸张力可评估在仿生驱逐。
Defecation is a complex process that is difficult to study and analyze. Here, we present new analytical tools to calculate frictional force and tension during expulsion of the Fecobionics simulated stool in human subjects. The 12-cm-long Fecobionics device contained pressure sensors, motion processor units for measurement of orientation and bending, and impedance rings for measurement of cross-sectional areas. Eight normal subjects defecated Fecobionics. The bending angle of the device, frictional force between the device and the surrounding tissue, and the stretch tensions were calculated. The bending angle and pressures changed during expulsion with the maximum pressure recorded at the rear. The averaged circumferential tension, longitudinal tension and friction force in each subject were associated with the front-rear pressure difference (r > 0.7, p < 0.005). The peak circumferential tension, longitudinal tension, and friction force immediately before expulsion of the rear were significantly higher compared to when the front entered the anal canal (F = 164.7, p < 0.005; F = 152.1, p < 0.005; F = 71.4, p < 0.005; respectively.). This study shows that Fecobionics obtained reliable data under physiological conditions. Mechanical features such as frictional force and stretch tensions were assessable during Fecobionics expulsion.
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影响因子：
3.3
作者：
Giavarina D
通讯作者：
Giavarina D
影响因子：
29.4
作者：
Kim, WR;Lindor, KD;Dickson, ER
通讯作者：
Dickson, ER
影响因子：
3.5
作者：
Andersen, IS;Gregersen, H;Laurberg, S
通讯作者：
Laurberg, S
影响因子：
12.6
作者：
Rao, Satish S. C.;Seaton, Kara;Schulze, Konrad
通讯作者：
Schulze, Konrad
影响因子：
--
作者：
Simren M;Palsson OS;Whitehead WE
通讯作者：
Whitehead WE