Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure.
Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure.
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DOI：
10.1016/j.hrthm.2009.01.006
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发表时间：
2009-04
期刊：
影响因子：
5.5
通讯作者：
Chen, Peng-Sheng
中科院分区：
文献类型：
--
作者：
Piccirillo, Gianfranco;Ogawa, Masahiro;Song, Juan;Chong, Voon J.;Joung, Boyoung;Han, Seongwook;Magri, Damiano;Chen, Lan S.;Lin, Shien-Fong;Chen, Peng-Sheng
关键词：
心率变异性（HRV），在频域或时域计算，降低充血性心力衰竭（CHF）。在HRV功率谱分析中，CHF患者的低频（LF）分量减少，并且这种减少与猝死风险增加有关。我们的目的是澄清正常和CHF犬HRV功率谱分析的性质。使用植入式无线电发射器，我们直接研究了6只动态犬起搏诱导CHF前后的综合左星状神经节神经活动（iSGNA）、综合迷走神经活动（iVNA）和心电图描记。在HRV的短期功率谱分析中，我们测量了高、中、低交感神经和迷走神经活动期间的功率谱密度。我们分析了38个数据段，这些数据段在基线和起搏诱导的CHF后具有相同的自主神经活动模式。与基线相比，CHF期间的频谱变量显示总功率（P = 0.002）、LF功率（P <0.0001）和LF/高频（HF）比值（P = 0.005）降低，iVNA和iSGNA升高（两者均P <0.0001）。仅在基线时，iSGNA与LF功率呈正相关（P <0.05，r = 0.314）。在相同条件下，iVNA与以标准化单位表示的HF分量呈正相关（P <0.05，r = 0.394），与以绝对功率（P <0.05，r =-0.464）和标准化单位（P <0.05，r =-0.425）表示的LF分量呈负相关。频谱变量（LF功率和LF/HF比值）和测量交感神经活动的直接变量（iSGNA）在基线时相关，但在CHF期间不相关。基线时，迷走神经活动（iVNA）与HFnu增加和LFnu减少相关。这些数据表明，在心力衰竭犬中观察到的LF功率和LF/HF比的降低可能反映了窦房结对自主调节的反应性降低或压力反射功能异常，而不是交感神经活动增加。
Heart rate variability (HRV), calculated in the frequency or time domain, decreases in congestive heart failure (CHF). In HRV power spectral analysis, the low-frequency (LF) component diminishes in patients with CHF and the decrease is related to an increased risk of sudden death. Our aim was to clarify the nature of HRV power spectral analysis in normal and CHF dogs. Using an implanted radiotransmitter, we directly studied integrated left stellate ganglion nerve activity (iSGNA), integrated vagal nerve activity (iVNA), and electrocardiographic tracings before and after pacing-induced CHF in 6 ambulatory dogs. In a short-term power spectral analysis of HRV, we measured power spectral density during high, medium, and low sympathetic and vagal nerve activity. We analyzed 38 data segments characterized by the same autonomic nerve activity patterns at baseline and after pacing-induced CHF. As compared with baseline, the spectral variables during CHF showed decreased total power (P = .002), LF power (P < .0001), and the LF/high frequency (HF) ratio (P = .005) and increased iVNA and iSGNA (P < .0001 for both). Only at baseline, iSGNA correlated positively with LF power (P < .05, r = 0.314). Under the same condition iVNA correlated positively with the HF component expressed as normalized units (P < .05, r = 0.394) and negatively with the LF component expressed both as absolute power (P < .05, r = −0.464) and normalized units (P < .05, r = −0.425). The spectral variables (LF power and the LF/HF ratio) and direct variables measuring sympathetic nerve activity (iSGNA) correlate at baseline but not during CHF. At baseline, the vagal activity (iVNA) is associated with an increase in HFnu and a decrease in LFnu. These data indicate that the reduction in LF power and LF/HF ratio observed in heart failure dogs are likely to reflect a diminished sinus node responsiveness to autonomic modulation or an abnormal baroreflex function rather than an increased sympathetic activity.
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