Prevalence and risk factors for insomnia among breast cancer patients on aromatase inhibitors.
Prevalence and risk factors for insomnia among breast cancer patients on aromatase inhibitors.
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DOI：
10.1007/s00520-012-1490-z
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发表时间：
2013-01
影响因子：
3.1
通讯作者：
Gehrman, Philip R.
中科院分区：
文献类型：
--
作者：
Desai, Krupali;Mao, Jun J.;Su, Irene;DeMichele, Angela;Li, Qing;Xie, Sharon X.;Gehrman, Philip R.
越来越多的人认识到乳腺癌的主要症状结果;然而，对于接受芳香化酶抑制剂（AIs）的女性的患病率和风险因素知之甚少，AIs是一种标准治疗方法，可增加乳腺癌患者的无病生存率。在一家大型大学医院的乳腺肿瘤门诊接受辅助AI治疗的0-III期乳腺癌绝经后妇女中进行了一项横断面调查研究。将神经功能缺损严重程度指数（ISI）用作主要结局。进行多因素logistic回归分析以评估危险因素。在413名参与者中，130名（31.5%）在ISI上有阈下失眠，77名（18.64%）超过临床显著失眠的阈值。在多变量逻辑回归模型中，临床显著失眠与严重关节疼痛独立相关（校正比值比，4.84，95%置信区间，1.71-13.69，P=0.003），轻度/中度潮热（AOR，2.28，95% CI，1.13-4.60，P=0.02），重度潮热（AOR，2.29，95%CI，1.23-6.81，P=0.015）、焦虑（AOR，1.99，95%CI，1.08-3.65，P=0.027）和抑郁（AOR，3.57，95%CI，1.48-8.52，P=0.004）。年龄（>65岁vs. <55岁，AOR，2.31，95%CI，1.11-4.81，p=0.026）和自乳腺癌诊断以来的时间（<2年vs. 2-5年，AOR，1.94，95%CI，1.02-3.69，p=0.045）也被发现是重要的风险因素。临床失眠在那些使用治疗失眠和疼痛的药物的人中更常见。人工智能用户的投诉率超过50%。临床上显著的失眠与关节疼痛、潮热、焦虑和抑郁、年龄和自诊断以来的时间高度相关。
Insomnia is increasingly recognized as a major symptom outcome in breast cancer; however, little is known about its prevalence and risk factors among women receiving aromatase inhibitors (AIs), a standard treatment to increase disease free survival among breast cancer patients. A cross-sectional survey study was conducted among postmenopausal women with stage 0-III breast cancer receiving adjuvant AI therapy at an outpatient breast oncology clinic of a large university hospital. The Insomnia Severity Index (ISI) was used as the primary outcome. Multivariate logistic regression analyses were performed to evaluate risk factors. Among 413 participants, 130 (31.5%) had sub-threshold insomnia on the ISI and 77 (18.64%) exceeded the threshold for clinically significant insomnia. In a multivariate logistic regression model, clinically significant insomnia was independently associated with severe joint pain (adjusted odds ratio, 4.84, 95% confidence interval, 1.71–13.69, P=0.003), mild/moderate hot flashes (AOR, 2.28, 95% CI, 1.13–4.60, P=0.02), severe hot flashes (AOR, 2.29, 95% CI, 1.23–6.81, P=0.015), anxiety (AOR, 1.99, 95% CI, 1.08–3.65, P=0.027), and depression (AOR, 3.57, 95% CI, 1.48–8.52, P=0.004). Age (>65 vs. <55 years, AOR, 2.31, 95% CI, 1.11–4.81, p=0.026), and time since breast cancer diagnosis (<2 years vs. 2–5 years, AOR, 1.94, 95% CI, 1.02–3.69, p=0.045) were also found to be significant risk factors. Clinical insomnia was more common among those who used medication for treating insomnia and pain. Insomnia complaints exceed 50% among AI users. Clinically significant insomnia is highly associated with joint pain, hot flashes, anxiety and depression, age, and time since diagnosis.
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影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.
影响因子：
7
作者：
CARROLL, BT;KATHOL, RG;CLAMON, GH
通讯作者：
CLAMON, GH
影响因子：
3.1
作者：
Ebben, Matthew R.;Spielman, Arthur J.
通讯作者：
Spielman, Arthur J.
乳腺癌幸存者中与芳香酶抑制剂相关的关节痛的模式和危险因素。
影响因子：
6.2
作者：
Mao JJ;Stricker C;Bruner D;Xie S;Bowman MA;Farrar JT;Greene BT;DeMichele A
通讯作者：
DeMichele A
影响因子：
3
作者：
Garreau, Jennifer R.;DeLaMelena, Tammy;Johnson, Nathalie
通讯作者：
Johnson, Nathalie