Neural correlates of visual search in patients with hereditary retinal dystrophies

Neural correlates of visual search in patients with hereditary retinal dystrophies
复制标题

遗传性视网膜营养不良患者视觉搜索的神经相关性

DOI:
10.1002/hbm.22088
复制
发表时间:
2013
影响因子:
4.8
通讯作者:
Greenlee
Greenlee
中科院分区:
医学2区
文献类型:
--
作者:
Farzana;Brandl-Rühle;Renner;Greenlee

文献摘要

参考文献

被引文献

相似文献

在中央视野暗点的患者中,很大一部分视觉皮层没有受到充分的刺激。我们调查了 22 名因遗传性视网膜营养不良(斯塔加特病、其他形式的遗传性黄斑营养不良和视杆细胞营养不良)而导致中央视野丧失的患者(8 名女性,14 名男性;平均年龄 41.5 岁,范围 12-65 岁)皮质反应可能上调的证据,并将他们的结果与 22 名年龄匹配的对照者(11 名女性,11 名男性;平均年龄,42.4 岁,范围,13-70 岁)。使用功能磁共振成像 (fMRI),我们记录了视网膜专题映射和视觉搜索任务中行为和 BOLD 信号分布的差异。具有已确定的首选视网膜位点 (PRL) 的患者在视觉搜索任务期间,早期视觉皮层表现出显着较高的激活,特别是在目标刺激落在 PRL 附近的试验中。与固定稳定性较差的患者相比,PRL 处偏心固定稳定的患者表现出更高的表现水平和更多的大脑激活。 Hum Brain Mapp 34:2607–2623, 2013。© 2012 Wiley periodicals, Inc.
In patients with central visual field scotomata a large part of visual cortex is not adequately stimulated. We investigated evidence for possible upregulation in cortical responses in 22 patients (8 females, 14 males; mean age 41.5 years, range 12–65 years) with central visual field loss due to hereditary retinal dystrophies (Stargardt's disease, other forms of hereditary macular dystrophies and cone‐rod dystrophy) and compared their results to those of 22 age‐matched controls (11 females, 11 males; mean age, 42.4 years, range, 13–70 years). Using functional magnetic resonance imaging (fMRI) we recorded differences in behavioral and BOLD signal distribution in retinotopic mapping and visual search tasks. Patients with an established preferred retinal locus (PRL) exhibited significantly higher activation in early visual cortex during the visual search task, especially on trials when the target stimuli fell in the vicinity of the PRL. Compared with those with less stable fixation, patients with stable eccentric fixation at the PRL exhibited greater performance levels and more brain activation. Hum Brain Mapp 34:2607–2623, 2013. © 2012 Wiley Periodicals, Inc.
DOI: --
发表时间: 1988-02
影响因子: 4.4
作者:
Stephen G. Whirraker;James Dudd;ond Roger W. Cummings
通讯作者: Stephen G. Whirraker;James Dudd;ond Roger W. Cummings
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者:
H. Baseler;A. Gouws;A. Morland
通讯作者: A. Morland
黄斑暗点的固视行为和阅读能力:通过 Tuebingen 手动视野检查和扫描激光检眼镜评估
DOI: --
发表时间: 1996
期刊:
影响因子: --
作者:
S. Trauzettel;R. Tornow
通讯作者: R. Tornow
扫描文本的视网膜轨迹。
DOI: --
发表时间: 2006
影响因子: --
作者:
G. Timberlake;M. Sharma;S. A. Grose;J. Maino
通讯作者: J. Maino
DOI: 10.1080/01658100902998732
发表时间: 2009-01-01
影响因子: 0.8
作者:
Rubin, Gary S.;Feely, Mary
通讯作者: Feely, Mary