Neural correlates of visual search in patients with hereditary retinal dystrophies
Neural correlates of visual search in patients with hereditary retinal dystrophies
复制标题
遗传性视网膜营养不良患者视觉搜索的神经相关性
DOI:
10.1002/hbm.22088
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发表时间:
2013
影响因子:
4.8
通讯作者:
Greenlee
中科院分区:
文献类型:
--
作者:
Farzana;Brandl-Rühle;Renner;Greenlee
In patients with central visual field scotomata a large part of visual cortex is not adequately stimulated. We investigated evidence for possible upregulation in cortical responses in 22 patients (8 females, 14 males; mean age 41.5 years, range 12–65 years) with central visual field loss due to hereditary retinal dystrophies (Stargardt's disease, other forms of hereditary macular dystrophies and cone‐rod dystrophy) and compared their results to those of 22 age‐matched controls (11 females, 11 males; mean age, 42.4 years, range, 13–70 years). Using functional magnetic resonance imaging (fMRI) we recorded differences in behavioral and BOLD signal distribution in retinotopic mapping and visual search tasks. Patients with an established preferred retinal locus (PRL) exhibited significantly higher activation in early visual cortex during the visual search task, especially on trials when the target stimuli fell in the vicinity of the PRL. Compared with those with less stable fixation, patients with stable eccentric fixation at the PRL exhibited greater performance levels and more brain activation. Hum Brain Mapp 34:2607–2623, 2013. © 2012 Wiley Periodicals, Inc.
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影响因子:
4.4
作者:
Stephen G. Whirraker;James Dudd;ond Roger W. Cummings
通讯作者:
Stephen G. Whirraker;James Dudd;ond Roger W. Cummings
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
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通讯作者:
A. Morland
DOI:
--
发表时间:
1996
期刊:
影响因子:
--
作者:
S. Trauzettel;R. Tornow
通讯作者:
R. Tornow
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作者:
G. Timberlake;M. Sharma;S. A. Grose;J. Maino
通讯作者:
J. Maino
影响因子:
0.8
作者:
Rubin, Gary S.;Feely, Mary
通讯作者:
Feely, Mary