The Organization of the Visual Cortex in Patients with Scotomata Resulting from Lesions of the Central Retina

The Organization of the Visual Cortex in Patients with Scotomata Resulting from Lesions of the Central Retina
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中央视网膜病变引起的暗点患者视觉皮层的组织

DOI:
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发表时间:
2009
期刊:
影响因子:
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通讯作者:
A. Morland
A. Morland
中科院分区:
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文献类型:
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作者:
H. Baseler;A. Gouws;A. Morland

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动物视网膜双侧损伤后,初级视皮层会发生各种形式的重组。最初从受损的视网膜组织接收输入的脑细胞对保持完整的视网膜做出反应。在人类中,在患有先天性中央凹病变的成年患者中发现了初级视觉皮层的重组。最近对黄斑变性患者的调查,谁获得视网膜病变后,产生了混合的结果。在本文中,我们回顾了人类和动物的皮质重组的证据和特点,并提出了如何在治疗视网膜疾病的策略的背景下进行评估。
Primary visual cortex can undergo forms of reorganization following bilateral lesions to the retinas of animals. Brain cells that originally received input from retinal tissue that was lesioned become responsive to retina that remains intact. In humans, reorganization of the primary visual cortex has been found in adult patients with congenital foveal lesions. More recent investigations of patients with macular degeneration, who acquired retinal lesions later, have yielded mixed results. In this paper we review the evidence for and characteristics of cortical reorganization in humans and animals and suggest how it might be evaluated in the context of strategies for treating retinal disease.
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