Drosophila as a model for age-related impairment in locomotor and other behaviors.
Drosophila as a model for age-related impairment in locomotor and other behaviors.
复制标题
DOI：
10.1016/j.exger.2010.08.012
复制
发表时间：
2011-05
影响因子：
3.9
通讯作者：
Grotewiel, Mike
中科院分区：
文献类型：
--
作者：
Jones, Melanie A.;Grotewiel, Mike
Aging is a multifaceted phenomenon that occurs in most species including humans and the fruit fly, Drosophila melanogaster. One of the most fundamental features of aging is the progressive decline in functional capacity that occurs with age (i.e. functional senescence). Age-related declines in function undermine many aspects of normal youthful physiology including behavior. Age-related behavioral declines are quite telling because they presumably reflect primary functional defects in the nervous system or musculature. Consequently, a more detailed understanding of behavioral declines that occur with age, including mechanisms that impinge on them, could ultimately lead to improved treatment or diagnosis of age-related defects in physiological processes that depend on normal function of the nervous system or musculature. Such advances in diagnosis or treatment would translate into tremendous gains in quality of life for elderly populations. In this article, we review progress using Drosophila to better understand age-related behavioral declines with a focus on age-related locomotor impairment.
登录
查看更多内容
影响因子：
2.4
作者：
Bushey D;Hughes KA;Tononi G;Cirelli C
通讯作者：
Cirelli C
DOI：
10.1111/j.1532-5415.2007.01413.x
发表时间：
2007-11-01
影响因子：
6.3
作者：
Hardy, Susan E.;Perera, Subashan;Studenski, Stephanie A.
通讯作者：
Studenski, Stephanie A.
DOI：
10.1093/geronj/42.1.78
发表时间：
1987-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
INGRAM, DK;WEINDRUCH, R;WALFORD, RL
通讯作者：
WALFORD, RL
衰老和痴呆症中的睡眠障碍
影响因子：
5.8
作者：
Bombois, S.;Derambure, P.;Monaca, C.
通讯作者：
Monaca, C.
影响因子：
7.8
作者：
Burger, Joep M. S.;Buechel, Severine D.;Kawecki, Tadeusz J.
通讯作者：
Kawecki, Tadeusz J.