Cis-regulatory change and expression divergence between duplicate genes formed by genome duplication of Arabidopsis thaliana
Cis-regulatory change and expression divergence between duplicate genes formed by genome duplication of Arabidopsis thaliana
复制标题
拟南芥基因组复制形成的重复基因之间的顺式调控变化和表达差异
DOI：
10.1007/s11434-010-3027-5
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Tang Tian
中科院分区：
文献类型：
--
作者：
Zhang Yanbin;Chen Kenian;Shi Suhua;Tang Tian
作为功能差异的指标，重复基因拷贝之间的表达差异已被观察到，并与蛋白质编码序列的差异和基因功能类别的偏倚相关。然而，在重复基因的顺式调控区的变化，这被认为是有重要作用的表达分歧，还没有在全基因组范围内探索。我们分析了功能基因组学数据的大量重复基因对形成的古老的多倍体事件在拟南芥。两个拷贝之间的顺式调控区的差异与表达的幅度差异呈正相关。此外，我们发现，高表达的重复基因对有一个更分歧的顺式调控区比弱表达的基因对。我们还发现，表达功能约束和蛋白质功能约束之间的相关性是不同的，在老和年轻的重复对。我们的研究结果表明，顺式调控序列的差异有助于重复基因的表达差异形成的全基因组复制。顺式调控区在高度表达的重复对中发散得更快。在表达限制条件下，作用于顺式调控区和蛋白质编码区的多样性选择强度在年轻重复对中呈负相关。
As an index of functional divergence, expression divergence between duplicate gene copies has been observed and correlated with protein coding sequence divergence and bias in gene functional classes. However, the changes in the cis-regulatory region of the duplicate genes which is thought to have important role in expression divergence, has not been explored on the genome-wide scale. We analyzed functional genomics data for a large number of duplicated gene pairs formed by ancient polyploidy events in Arabidopsis thaliana. The divergence in cis-regulatory regions between two copies is positively correlated with the magnitude difference of expression. Moreover, we find that highly expressed duplicate gene pairs have a more diverged cis-regulatory region than weakly expressed gene pairs. We also show that the correlation between expression functional constraint and protein functional constraint is different in old and young duplicate pairs. Our results suggest that cis-regulatory sequence divergence contributes to the expression divergence of duplicate genes formed by genome-wide duplication. Cis-regulatory region diverges faster in highly expressed duplicate pairs. The diversify selection strengths that act on cis-regulatory region and protein coding region are negatively correlated in young duplicate pairs under expression constraint.
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影响因子：
7
作者：
Blanc, G;Hokamp, K;Wolfe, KH
通讯作者：
Wolfe, KH
影响因子：
7.4
作者：
Haberer, G;Hindemitt, T;Mayer, KFX
通讯作者：
Mayer, KFX
影响因子：
3.3
作者：
A. Reinisch;Jianghan Dong;C. Brubaker;D. Stelly;J. Wendel;A. Paterson
通讯作者：
A. Reinisch;Jianghan Dong;C. Brubaker;D. Stelly;J. Wendel;A. Paterson
影响因子：
56.9
作者：
Vision, TJ;Brown, DG;Tanksley, SD
通讯作者：
Tanksley, SD
DOI：
10.1073/pnas.0501102102
发表时间：
2005-04-12
影响因子：
11.1
作者：
Maere, S;De Bodt, S;Van de Peer, Y
通讯作者：
Van de Peer, Y