Ethnic and sex differences in skeletal maturation among the Birth to Twenty cohort in South Africa.
Ethnic and sex differences in skeletal maturation among the Birth to Twenty cohort in South Africa.
复制标题
DOI：
10.1136/archdischild-2014-306399
复制
发表时间：
2015-02
影响因子：
5.2
通讯作者：
Pettifor JM
中科院分区：
文献类型：
--
作者：
Cole TJ;Rousham EK;Hawley NL;Cameron N;Norris SA;Pettifor JM
使用一种新的纵向分析技术（平移和旋转叠加（SITAR）），研究从青春期到成年期骨骼成熟模式的种族和性别差异。南非约翰内斯堡。607名黑人和白色种族的男孩和女孩，来自出生至20岁骨骼健康研究，每年评估9至20岁。 骨成熟度评分（Tanner-Whitehouse III桡骨、尺骨和短骨（TW 3罗斯））根据手腕X线片进行纵向评估，用于生成骨成熟度的个体和平均生长曲线，并通过SITAR方法进行分析。纵向分析显示，黑人男孩比白人男孩成熟晚7.0 SE 1.6个月（p<0.0001），但速度与白色男孩相同，而黑人女孩比白色女孩成熟年龄相同，但速度更快（8.7% SE 2.6%，p=0.0007）。 骨成熟度评分的平均曲线始终显示青春期中期双扭结，与骨成熟度常用参考百分位数曲线（TW 3）的二次形状形成对比。女孩的骨骼发育成熟比男孩早1.9年，而且性别之间的成熟模式不同。在女孩中，骨骼成熟的模式或时间没有种族差异。然而，在男孩中，与白色种族相比，黑人的骨骼成熟延迟了7个月。 因此，骨骼成熟度因性别和种族而异。黑人男孩的延迟成熟，而不是黑人女孩，支持男孩比女孩对环境约束更敏感的假设。
To examine ethnic and sex differences in the pattern of skeletal maturity from adolescence to adulthood using a novel longitudinal analysis technique (SuperImposition by Translation And Rotation (SITAR)). Johannesburg, South Africa. 607 boys and girls of black as well as white ethnicity from the Birth to Twenty bone health study, assessed annually from 9 to 20 years of age. Bone maturity scores (Tanner–Whitehouse III radius, ulna, and short bones (TW3 RUS)) assessed longitudinally from hand-wrist radiographs were used to produce individual and mean growth curves of bone maturity and analysed by the SITAR method. The longitudinal analysis showed that black boys matured later by 7.0 SE 1.6 months (p<0.0001) but at the same rate as white boys, whereas black girls matured at the same age but at a faster rate than white girls (by 8.7% SE 2.6%, p=0.0007). The mean curves for bone maturity score consistently showed a midpubertal double kink, contrasting with the quadratic shape of the commonly used reference centile curves for bone maturity (TW3). Skeletal maturity was reached 1.9 years earlier in girls than boys, and the pattern of maturation differed between the sexes. Within girls, there were no ethnic differences in the pattern or timing of skeletal maturity. Within boys, however, skeletal maturity was delayed by 7 months in black compared with white ethnicity. Skeletal maturation, therefore, varies differentially by sex and ethnicity. The delayed maturity of black boys, but not black girls, supports the hypothesis that boys have greater sensitivity to environmental constraints than girls.
登录
查看更多内容
影响因子：
7.7
作者：
Cole TJ;Donaldson MD;Ben-Shlomo Y
通讯作者：
Ben-Shlomo Y
影响因子：
1.7
作者：
Cole TJ;Pan H;Butler GE
通讯作者：
Butler GE
影响因子：
2.8
作者：
Richter, LM;Norris, SA;De Wet, T
通讯作者：
De Wet, T
影响因子：
7.7
作者：
Richter, Linda;Norris, Shane;Cameron, Noel
通讯作者：
Cameron, Noel
影响因子：
8
作者：
Biro, Frank M.;Greenspan, Louise C.;Wolff, Mary S.
通讯作者：
Wolff, Mary S.