A mixed effects model to estimate timing and intensity of pubertal growth from height and secondary sexual characteristics.
A mixed effects model to estimate timing and intensity of pubertal growth from height and secondary sexual characteristics.
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DOI：
10.3109/03014460.2013.856472
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发表时间：
2014-01
影响因子：
1.7
通讯作者：
Butler GE
中科院分区：
文献类型：
--
作者：
Cole TJ;Pan H;Butler GE
估计和比较青春期生长时间和强度的身高，坦纳阶段标记和睾丸体积。对爱丁堡纵向生长研究中103名男孩和74名女孩的身高、生殖器期、乳房期和阴毛期、睾丸体积和月经初潮等数据进行了分析。身高的SITAR模型和坦纳分期和睾丸体积的新型混合效应logistic模型提供了峰值速度（PV，强度）和峰值速度时的年龄（APV，时间）的估计值，包括总体（来自固定效应）和个体（随机效应）。基于这6个标志物，男孩的平均APV为13.0-14.0岁，女孩为12.0-13.1岁，受试者间标准差为10.1岁。身高的PV按性别为8-9 cm/年，睾丸体积为6 ml/年，而坦纳分期在其高峰期每年增加1.2-1.8期。APV标记物之间的相关性对于男孩为0.6-0.8，对于女孩为0.8-0.92，对于女孩非常显著地更高（p = 0.005）。PV的相关性较低，为-0.2-0.6。混合效应模型在估计个体跨越几个青春期标志物的时间和强度方面表现良好。峰值流速时的年龄在各标记物之间高度相关，但峰值流速的相关性较低。
To estimate and compare pubertal growth timing and intensity in height, Tanner stage markers and testis volume. Data on height, genital stage, breast stage and pubic hair stage, testis volume and menarche in 103 boys and 74 girls from the Edinburgh Longitudinal Growth Study were analysed. The SITAR model for height and a novel mixed effects logistic model for Tanner stage and testis volume provided estimates of peak velocity (PV, intensity) and age at peak velocity (APV, timing), both overall (from fixed effects) and for individuals (random effects). Based on the six markers, mean APV was 13.0–14.0 years in boys and 12.0–13.1 years in girls, with between-subject standard deviations of ∼1 year. PV for height was 8–9 cm/year by sex and for testis volume 6 ml/year, while Tanner stage increased by 1.2–1.8 stages per year at its peak. The correlations across markers for APV were 0.6–0.8 for boys and 0.8–0.92 for girls, very significantly higher for girls (p = 0.005). Correlations for PV were lower, −0.2–0.6. The mixed effects models perform well in estimating timing and intensity in individuals across several puberty markers. Age at peak velocity correlates highly across markers, but peak velocity less so.
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影响因子：
7.7
作者：
Cole TJ;Donaldson MD;Ben-Shlomo Y
通讯作者：
Ben-Shlomo Y
影响因子：
3.2
作者：
BUTLER, GE;WALKER, RF;RATCLIFFE, SG
通讯作者：
RATCLIFFE, SG
影响因子：
1.7
作者：
Molinari, Luciano;Gasser, Theo;Largo, Remo
通讯作者：
Largo, Remo
影响因子：
5.2
作者：
TANNER, JM;WHITEHOUSE, RH;TAKAISHI, M
通讯作者：
TAKAISHI, M
影响因子：
5.8
作者：
Sandhu, Jat;Smith, George Davey;Ben-Shlomo, Yoav
通讯作者：
Ben-Shlomo, Yoav