Differential regenerative capacity of neonatal mouse hearts after cryoinjury.
Differential regenerative capacity of neonatal mouse hearts after cryoinjury.
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DOI：
10.1016/j.ydbio.2014.12.018
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发表时间：
2015-03-01
影响因子：
2.7
通讯作者：
Lien, Ching-Ling
中科院分区：
文献类型：
--
作者：
Darehzereshki, Ali;Rubin, Nicole;Gamba, Laurent;Kim, Jieun;Fraser, James;Huang, Ying;Billings, Joshua;Mohammadzadeh, Robabeh;Wood, John;Warburton, David;Kaartinen, Vesa;Lien, Ching-Ling
关键词：
新生小鼠心室切除后心脏完全再生，类似于成年斑马鱼。我们建立了冷冻损伤模型，以确定不同类型和不同程度的心脏损伤是否会引发新生小鼠心脏的不同反应。与心室切除术相反，新生小鼠心脏不能再生，并显示透壁冷冻损伤后心脏功能严重受损。然而，新生儿心脏完全恢复后，非透壁冷冻损伤。有趣的是，心肌细胞增殖并没有显着增加新生小鼠心脏冷冻损伤后。冷冻损伤后发生心外膜激活和新冠状血管形成。促纤维化标志派-1在透壁冷冻损伤后高度表达，而非透壁冷冻损伤后高度表达，这可能有助于差异性瘢痕形成。我们的研究结果表明，心脏损伤的再生医学策略应根据损伤的性质而有所不同。
Neonatal mouse hearts fully regenerate after ventricular resection similar to adult zebrafish. We established cryoinjury models to determine if different types and varying degrees of severity in cardiac injuries trigger different responses in neonatal mouse hearts. In contrast to ventricular resection, neonatal mouse hearts fail to regenerate and show severe impairment of cardiac function post transmural cryoinjury. However, neonatal hearts fully recover after non-transmural cryoinjury. Interestingly, cardiomyocyte proliferation does not significantly increase in neonatal mouse hearts after cryoinjuries. Epicardial activation and new coronary vessel formation occur after cryoinjury. The profibrotic marker PAI-1 is highly expressed after transmural but not non-transmural cryoinjuries, which may contribute to the differential scarring. Our results suggest that regenerative medicine strategies for heart injuries should vary depending on the nature of the injury.
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