Abnormal modulation of serum osteocalcin by dietary phosphate and 1,25‐dihydroxyvitamin D3 in the hypophosphatemic mouse
Abnormal modulation of serum osteocalcin by dietary phosphate and 1,25‐dihydroxyvitamin D3 in the hypophosphatemic mouse
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膳食磷酸盐和 1,25-二羟基维生素 D3 对低磷血症小鼠血清骨钙素的异常调节
DOI：
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发表时间：
1996
影响因子：
6.2
通讯作者：
B. Ecarot
中科院分区：
文献类型：
--
作者：
H. Tsuji;C. Cawthorn;B. Ecarot
我们在正常和低磷血症 (Hyp) 小鼠中评估了膳食磷酸盐补充剂、甲状旁腺激素 (PTH) 和 1,25-二羟基维生素 D3 (1,25(OH)2D3) 给药引起的骨钙素血清水平变化是否与磷酸钙稳态扰动有关。在正常小鼠中，补充磷酸盐不会改变血清骨钙素水平。相比之下，Hyp 小鼠补充磷酸盐导致 3 天后血清骨钙素下降 2 倍至正常水平，14 天后骨钙素水平增加。骨钙素的降低与血磷正常、严重低钙血症和循环 1,25(OH)2D3 水平显着升高相关，而骨钙素水平的升高与血磷正常且血清钙和 1,25(OH)2D3 没有变化相关。 PTH 的施用降低了两种基因型的血清骨钙素。输注 1,25(OH)2D3 3 天后，正常小鼠的血清骨钙素和钙水平升高，而 Hyp 小鼠的骨钙素水平显着降低，而血清钙没有变化。然而，随着 1,25(OH)2D3 输注时间的延长，突变小鼠中会诱导高钙血症和血清骨钙素增加。我们的结果表明，Hyp 小鼠的异常骨钙素反应并不直接归因于成骨细胞功能障碍，而是继发于（至少部分）调节成骨细胞活性的因素（尤其是血清钙和/或 PTH）的扰动。
We evaluated in normal and hypophosphatemic (Hyp) mice whether changes in serum levels of osteocalcin in response to dietary phosphate supplementation, parathyroid hormone (PTH) and 1,25‐dihydroxyvitamin D3 (1,25(OH)2D3) administration were related to perturbations in calcium phosphate homeostasis. In normal mice, serum osteocalcin levels were not altered by phosphate supplementation. In contrast, phosphate supplementation in Hyp mice led to a 2‐fold decrease in serum osteocalcin to normal levels after 3 days and to an increase in osteocalcin levels after 14 days. The decrease in osteocalcin was associated with normophosphatemia, severe hypocalcemia, and marked increases in circulating 1,25(OH)2D3 levels, whereas the increase in osteocalcin levels was associated with normophosphatemia and no change in serum calcium and 1,25(OH)2D3. Administration of PTH decreased serum osteocalcin in both genotypes. Infusion of 1,25(OH)2D3 for 3 days elicited increases in serum osteocalcin and calcium levels in normal mice, whereas in Hyp mice it produced significant decreases in osteocalcin levels and no change in serum calcium. However, with a more prolonged infusion of 1,25(OH)2D3, hypercalcemia and increases in serum osteocalcin were induced in mutant mice. Our results suggest that the abnormal osteocalcin response of Hyp mice is not directly attributable to an osteoblast dysfunction but is secondary, at least in part, to perturbations in factors that modulate the osteoblast activity, especially serum calcium and/or PTH.
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
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DOI：
--
发表时间：
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期刊：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1172/jci112274
发表时间：
1986
期刊：
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影响因子：
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作者：
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DOI：
10.1210/jcem-72-2-438
发表时间：
1991
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
Gundberg,CM;Grant,FD;Conlin,PR;Chen,CJ;Brown,EM;Johnson,PJ;LeBoff,MS
通讯作者：
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