β-amyloid dynamics in human plasma.
β-amyloid dynamics in human plasma.
复制标题
人血浆中的β-淀粉样动力学。
DOI：
10.1001/archneurol.2012.18107
复制
发表时间：
2012-12
影响因子：
--
通讯作者：
Bateman RJ
中科院分区：
文献类型：
--
作者：
Huang Y;Potter R;Sigurdson W;Kasten T;Connors R;Morris JC;Benzinger T;Mintun M;Ashwood T;Ferm M;Budd SL;Bateman RJ
早期阿尔茨海默病(AD)患者脑脊液中A-β-42的显著降低已有文献记载。然而，关于血浆A-β水平作为AD诊断标记物的研究报道了相互矛盾的结果。研究人血浆Aβ水平的动态变化，评价衰老和淀粉样变性对这些动态变化的影响，并确定其与脑脊液Aβ水平的相关性。这是在圣路易斯的华盛顿大学医学院进行的一项重复的血浆和脑脊液采样研究。有淀粉样蛋白沉积的老年人(淀粉样蛋白+)、年龄匹配的无淀粉样蛋白沉积的对照组(淀粉样蛋白−)和较年轻的正常对照组(YNC)参加了研究。按年龄和淀粉样变性分组比较血浆A-β的每小时测量值。比较血浆Aβ和脑脊液Aβ水平的相关性、线性增加和昼夜节律模式。在血浆A-β中观察到昼夜节律，其幅度随着年龄的增长而减小。Aβ的线性增加仅在ync组和淀粉样蛋白β组观察到，而在淀粉样蛋白+组中未观察到。血浆A-β水平未见线性升高。血浆和脑脊液Aβ水平之间无显著相关性。血浆Aβ和脑脊液一样，表现出昼夜节律模式，其幅度随着年龄的增长而降低，但不受淀粉样蛋白沉积的影响。然而，我们没有发现任何证据表明血浆和脑脊液Aβ水平在每小时或个人基础上是相关的。
A marked decrease of Aβ42 in the cerebrospinal fluid (CSF) of patients with incipient Alzheimer's Disease (AD) has been well documented. However, contradictory results have been reported from studies on plasma Aβ levels as diagnostic markers for AD. To investigate dynamic changes in human plasma Aβ levels, evaluate the effects of aging and amyloidosis on these dynamics, and determine their correlation with CSF Aβ levels. This was a repeated plasma and CSF sampling study conducted at the Washington University School of Medicine in St. Louis. Older adults with amyloid deposition (Amyloid +), age-matched controls without amyloid deposition (Amyloid −), and younger normal controls (YNC) were enrolled for the study. Hourly measurements of plasma Aβ were compared between groups by age and amyloidosis. Plasma Aβ and CSF Aβ levels were compared for correlation, linear increase, and circadian patterns. Circadian patterns were observed in plasma Aβ, with diminished amplitudes with aging. Linear increase of Aβ was only observed for CSF Aβ in YNC and Amyloid − groups, but not in the Amyloid + group. No linear increase was observed for plasma Aβ. No significant correlations were found between plasma and CSF Aβ levels. Plasma Aβ, like CSF, demonstrates a circadian pattern which is reduced in amplitude with increasing age but is unaffected by amyloid deposition. However, we found no evidence that plasma and CSF Aβ levels were related on an hourly or individual basis.
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DOI：
10.1126/science.1180962
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kang JE;Lim MM;Bateman RJ;Lee JJ;Smyth LP;Cirrito JR;Fujiki N;Nishino S;Holtzman DM
通讯作者：
Holtzman DM
DOI：
10.1016/j.jalz.2010.08.230
发表时间：
2011-03
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Weigand SD;Vemuri P;Wiste HJ;Senjem ML;Pankratz VS;Aisen PS;Weiner MW;Petersen RC;Shaw LM;Trojanowski JQ;Knopman DS;Jack CR Jr;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
11.2
作者：
Tranah, Gregory J.;Blackwell, Terri;Stone, Katie L.;Ancoli-Israel, Sonia;Paudel, Misti L.;Ensrud, Kristine E.;Cauley, Jane A.;Redline, Susan;Hillier, Teresa A.;Cummings, Steven R.;Yaffe, Kristine
通讯作者：
Yaffe, Kristine
影响因子：
11.1
作者：
Fagan, Anne M.;Mintun, Mark A.;Shah, Aarti R.;Aldea, Patricia;Roe, Catherine M.;Mach, Robert H.;Marcus, Daniel;Morris, John C.;Holtzman, David M.
通讯作者：
Holtzman, David M.
影响因子：
--
作者：
ARONSON, MK;OOI, WL;FRISHMAN, W
通讯作者：
FRISHMAN, W