Analysis of T-cell receptor repertoire in peripheral blood of patients with pancreatic cancer and other pancreatic diseases.
Analysis of T-cell receptor repertoire in peripheral blood of patients with pancreatic cancer and other pancreatic diseases.
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DOI：
10.1111/jcmm.16358
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发表时间：
2021-04
影响因子：
5.3
通讯作者：
Lv Y
中科院分区：
文献类型：
--
作者：
Wang H;Yuan Y;Lu C;Zhou S;Zhang Y;Zhao J;Xu C;Yang J;Su H;Li B;Li X;Wang P;Xu G;Wang L;Zou X;Bao S;Zhang S;Lv Y
胰腺癌（PC）是全球第四大癌症相关死亡，由于其快速进展和早期症状很少，在不可切除的阶段被诊断。本研究的目的是确定PC和其他良性胰腺疾病患者T细胞受体（TCR）库的多样性与临床病理特征之间的相关性。为了对TCR库进行全面分析，使用高通量测序来区分来自3名PC、3名慢性胰腺炎、3名胰腺囊性病变和3名胰腺神经内分泌肿瘤患者的外周血样品中TCR β链的互补决定区3（CDR 3）。我们发现PC与其他胰腺疾病的TCR谱存在显著差异，PC是一种相对免疫抑制的肿瘤。外周血TCR谱的变化可用于预测PC的进展和对免疫治疗的反应。PC患者中可能存在新的特异性抗原，可用于设计靶向免疫治疗。
Pancreatic cancer (PC) has been the fourth cancer‐related death worldwide, diagnosed at an unresectable stage due to its rapid progression and few symptoms of this disease at early stages. The aim of this study was to determine the association between the diversity of T‐cell receptor (TCR) repertoire and clinicopathological characteristics of patients with PC and other benign pancreatic diseases. In order to make a comprehensive analysis the TCR repertoire, high‐throughput sequencing was used to differentiate complementarity determining region 3 (CDR3) of the TCR β chain in peripheral blood samples from 3 PC, 3 chronic pancreatitis, 3 pancreatic cystic lesions and 3 pancreatic neuroendocrine tumour patients. We found that there were significant differences related to TCR repertoire between PC and other pancreatic diseases, and PC is a relatively immunosuppressive tumour. Changes of peripheral TCR repertoire may be used to predict the progression of PC and the response to immunotherapy. And there may exist novel‐specific antigens in PC patients which could be used to design targeting immunotherapy in the nearly future.
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DOI：
10.1016/s0950-3552(05)80003-3
发表时间：
1992-09-01
期刊：
BAILLIERES CLINICAL OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
DUDLEY, DJ
通讯作者：
DUDLEY, DJ
高通量 T 细胞受体测序揭示了 HBV 相关 HCC 中肿瘤组织和邻近非肿瘤组织之间的独特特性
影响因子：
7.2
作者：
Chen, Yunqing;Xu, Ying;Wang, Zhanhui
通讯作者：
Wang, Zhanhui
影响因子：
5.7
作者：
Cui, Can;Tian, Xiuyun;Hao, Chunyi
通讯作者：
Hao, Chunyi
影响因子：
32.4
作者：
Noy, Roy;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.
影响因子：
3.7
作者：
Birtel J;Walser JC;Pichon S;Bürgmann H;Matthews B
通讯作者：
Matthews B