Recent advances in extracellular vesicles enriched with non-coding RNAs related to cancers.
Recent advances in extracellular vesicles enriched with non-coding RNAs related to cancers.
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富含与癌症相关的非编码RNA的细胞外囊泡的最新进展
DOI：
10.1016/j.gendis.2017.12.001
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发表时间：
2018-03
期刊：
影响因子：
6.8
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Yang S;Li X
细胞外囊泡（extracellular vesicles，EVs）是细胞间通讯系统中不可缺少的一部分，它可以被亲本细胞脱落，脱落后与其他细胞融合，释放出其内含物。EV内容物可能是所有种类的生物活性分子，包括非编码RNA（ncRNA），其是具有各种亚型的大而复杂的RNA组，其功能是调节生物事件，但传统上不编码蛋白质。在这篇综述中，我们涵盖了最近发表的工作，这些工作验证了调节EV相关ncRNA的生物发生，信号传导，特别是与癌症进展的任何阶段相关的全身生物效应的潜在分子机制，以及携带ncRNA的EV作为诊断生物标志物和药物递送系统的临床潜力，这些系统正在被设计用于更好的负载和靶向能力。我们也对未来的基础研究方向和应用的电动汽车含有ncRNA的意见进行了分享。
As membrane-bound structures that could be shedded by a parental cell, and fuse with others after shedding, and then release its contents, extracellular vesicles (EVs) are considered as an indispensable part of intercellular communication system. The EV contents might be all kinds of bioactive molecules including non-coding RNAs (ncRNAs), a large and complex group of RNAs with various subtypes that function to regulate biological events but classically do not code for proteins. In this review we covered the recently published works that validated the underlying molecular mechanisms regulating EV-associated ncRNAs' biogenesis, signaling, and particularly the systemic bio-effects related mostly to any stage of cancer progression, and the clinical potential of ncRNA-carrying EVs as diagnostic biomarkers and drug-delivery system that is being engineered for better loading and targeting capacity. Our views on the future direction of basic research and applications of EVs containing ncRNAs have also been shared.
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