Initial enamel crystals are not spatially associated with mineralized dentine
Initial enamel crystals are not spatially associated with mineralized dentine
复制标题
初始牙釉质晶体与矿化牙本质在空间上不相关
作者：
T. Diekwisch;Brett J. Berman;Steven Gentner;H. Slavkin
During epithelial-mesenchymal interactions associated with mammalian tooth development, epithelially-derived and mesenchymally-derived extracellular matrix molecules form a discrete dentine-enamel junction. The developmental and molecular processes required to form this junction are not known. To address this problem we designed studies to test the hypothesis that ectodermally-derived epithelial cells synthesize and secrete enamel proteins which function to nucleate and regulate the growth of enamel calcium phosphate crystals. Initial enamel crystals were detected separate from the adiacent dentine. Electron-microprobe analyses revealed that early enamel crystals were octacalciumphosphate or tricalciumphosphate rather than hydroxyapatite. Thereafter, enamel crystals became confluent with the adjacent, albeit significantly smaller hydroxyapatite crystals associated with mineralized dentine. Therefore, we interpret our data to indicate that de novo enamel crystal nucleation and growth are independent from the mineralization processes characterized for dentine. We further argue that gene expression of enamel protein appears to have a constitutive function during early enamel formation and that supramolecular aggregates of amelogenin and enamelin provide the microenvironment for the nucleation and crystal growth of the initial enamel matrix.
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影响因子：
4.6
作者：
Thomas GH Diekwisch;Sasson David;P. Bringas;V. Santos;Harold C. Slavkin
通讯作者：
Thomas GH Diekwisch;Sasson David;P. Bringas;V. Santos;Harold C. Slavkin
DOI：
10.1177/10454411920030010601
发表时间：
1992-01-01
期刊：
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE
影响因子：
--
作者：
JOHNSSON, MSA;NANCOLLAS, GH
通讯作者：
NANCOLLAS, GH
使用化学成分确定的培养基对体外发育过程中牙釉质形成进行超微结构分析。
DOI：
--
发表时间：
1987
期刊：
Scanning microscopy
影响因子：
--
作者：
BringasJr,P;Nakamura,M;Nakamura,E;Evans,J;Slavkin,HC
通讯作者：
Slavkin,HC
鲨齿鱼牙齿发育：III。
DOI：
--
发表时间：
1983
期刊：
Journal of craniofacial genetics and developmental biology
影响因子：
--
作者：
Nanci,A;BringasJr,P;Samuel,N;Slavkin,HC
通讯作者：
Slavkin,HC
DOI：
10.1016/0889-1605(86)90069-8
发表时间：
1986-03-01
期刊：
JOURNAL OF ULTRASTRUCTURE AND MOLECULAR STRUCTURE RESEARCH
影响因子：
--
作者：
LANDIS, WJ
通讯作者：
LANDIS, WJ