Analysis of breast cancer in young women in the Department of Defense (DOD) database.
Analysis of breast cancer in young women in the Department of Defense (DOD) database.
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DOI：
10.1007/s10549-017-4615-8
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发表时间：
2018-04
影响因子：
3.8
通讯作者：
Lipkowitz S
中科院分区：
文献类型：
--
作者：
Zimmer AS;Zhu K;Steeg PS;Wu A;Gatti-Mays ME;Soltani S;Perkins JG;Shao S;Brown D;Georg M;Hu H;Shriver CD;Lipkowitz S
Breast tumors from young women under the age of 40 account for approximately 7% of cases and have a poor prognosis independent of established prognostic factors. We evaluated the patient population served by the Military Health System, where a disproportionate number of breast cancer cases in young women are seen and treated in a single universal coverage healthcare system. The Military Health System Repository and the DoD Central Registration databases were used to identify female breast cancer patients diagnosed or treated at military treatment facilities from 1998 to 2007. 10,066 women were diagnosed with invasive breast cancer at DoD facilities from 1998 to 2007, of which 11.3% (1139), 23.4% (2355) and 65.2% (6572) were < 40, 40–49 and > 50 years old (yo), respectively, at diagnosis. 53% in the < 40 yo cohort were white, 25% were African American (AA) and 8% were Hispanic, with 14% undisclosed. Breast cancer in women diagnosed < 40 yo was more high grade (p < 0.0001), Stage II (p < 0.0001) and ER negative (p < 0.0001). There was a higher rate of bilateral mastectomies among the women < 40 compared to those 40–49 and > 50 (18.4% vs. 9.1% and 5.0%, respectively). Independent of disease stage, chemotherapy was given more frequently to < 40 yo (90.43%) and 40–49 yo (81.44%) than ≥ 50 yo (53.71%). The 10-year overall survival of younger women was similar to the ≥ 50 yo cohort. Outcomes in the African American and Hispanic subpopulations were comparable to the overall cohort. Younger women had a similar overall survival rate to older women despite receiving more aggressive treatment.
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影响因子：
8.8
作者：
Liu P;Li X;Mittendorf EA;Li J;Du XL;He J;Ren Y;Yang J;Hunt KK;Yi M
通讯作者：
Yi M
影响因子：
11.5
作者：
Azim, Hatem A., Jr.;Michiels, Stefan;Loi, Sherene
通讯作者：
Loi, Sherene
DOI：
10.1016/j.jamcollsurg.2008.12.001
发表时间：
2009-03
影响因子：
5.2
作者：
Gnerlich, Jennifer L.;Deshpande, Anjali D.;Jeffe, Donna B.;Sweet, Allison;White, Nick;Margenthaler, Julie A.
通讯作者：
Margenthaler, Julie A.
影响因子：
3.8
作者：
Kataoka, Akemi;Iwamoto, Takayuki;Tokunaga, Eriko;Tomotaki, Ai;Kumamaru, Hiraku;Miyata, Hiroaki;Niikura, Naoki;Kawai, Masaaki;Anan, Keisei;Hayashi, Naoki;Masuda, Shinobu;Tsugawa, Koichiro;Aogi, Kenjiro;Ishida, Takanori;Masuoka, Hideji;Iijima, Kotaro;Kinoshita, Takayuki;Nakamura, Seigo;Tokuda, Yutaka
通讯作者：
Tokuda, Yutaka
影响因子：
3.8
作者：
Murphy, Caitlin C.;Bartholomew, L. Kay;Carpentier, Melissa Y.;Bluethmann, Shirley M.;Vernon, Sally W.
通讯作者：
Vernon, Sally W.