Experimental Weight Gain Increases Ambulatory Blood Pressure in Healthy Subjects: Implications of Visceral Fat Accumulation.
Experimental Weight Gain Increases Ambulatory Blood Pressure in Healthy Subjects: Implications of Visceral Fat Accumulation.
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DOI：
10.1016/j.mayocp.2017.12.012
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发表时间：
2018-05
影响因子：
8.9
通讯作者：
Somers VK
中科院分区：
文献类型：
--
作者：
Covassin N;Sert-Kuniyoshi FH;Singh P;Romero-Corral A;Davison DE;Lopez-Jimenez F;Jensen MD;Somers VK
研究实验诱导的体重增加是否会升高健康受试者的动态血压（BP），并确定BP变化与局部脂肪分布变化之间的任何关系。2004年7月至2010年8月期间，26名正常体重受试者被随机分配至通过过度喂养增加体重8周（n=16;年龄30.4±6.6岁）或维持体重（对照组; n=10;年龄27.1±7.7岁）。在基线和8周实验期后，通过双能X线吸收法和计算机断层扫描测量身体成分、循环生物标志物和24小时动态血压。过度喂养导致增重者体重增加3.7 kg（95% CI 2.9，4.5），总体（46.2 cm 2，95% CI 27.6，64.9）、内脏（13.8 cm 2，95% CI 5.8，21.9）和皮下脂肪（32.4 cm 2，95% CI 13.5，51.3）增加。维护组中未发生任何更改。实验组体重增加后，24小时收缩压（4 mmHg，95% CI 1.6，6.3）、平均血压（1.7 mmHg，95% CI 0.3，3.3）和脉压（2.8 mmHg，95% CI 1.1，4.4）明显升高，而对照组血压保持不变。平均血压的变化仅与内脏脂肪的变化相关（rho=0.45，P= 0.02），但与其他身体成分指标的变化无关。适度的体重增加会导致健康受试者24小时BP升高。血压升高和腹部内脏脂肪堆积之间的关联表明，脂肪组织的内脏沉积可能特别有助于与体重增加相关的高血压风险增加。
To examine whether experimentally-induced weight gain raises ambulatory blood pressure (BP) in healthy subjects and identify any relationship between changes in BP and changes in regional fat distribution. Twenty-six normal weight subjects were randomized to 8 weeks of weight gain through overfeeding (n=16; age 30.4±6.6 years) or to weight maintenance (controls; n=10; age 27.1±7.7 years) between July, 2004, and August, 2010. Measures of body composition via dual energy X-ray absorptiometry and computed tomography, circulating biomarkers, and 24-hour ambulatory BP were obtained at baseline and after the 8-week experimental phase. Overfeeding resulted in 3.7 kg (95% CI 2.9, 4.5) increase in body weight in weight gainers, with increments in total (46.2 cm2, 95% CI 27.6, 64.9), visceral (13.8 cm2, 95% CI 5.8, 21.9), and subcutaneous fat (32.4 cm2, 95% CI 13.5, 51.3). No changes occurred in the maintenance group. Increases in 24-hour systolic BP (4 mmHg, 95% CI 1.6, 6.3), mean BP (1.7 mmHg, 95% CI 0.3, 3.3), and pulse pressure (2.8 mmHg, 95% CI 1.1, 4.4) were evident following weight gain in the experimental group, while BP remained unchanged in controls. Changes in mean BP correlated only with changes in visceral fat (rho=0.45, P=.02), but not with changes in other body composition measures. Modest weight gain causes elevation in 24-hour BP in healthy subjects. The association between increased BP and abdominal visceral fat accumulation suggests that visceral deposition of adipose tissue may contribute specifically to the enhanced risk of hypertension associated with weight gain.
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影响因子：
8.3
作者：
Engeli, S;Bohnke, J;Sharma, AM
通讯作者：
Sharma, AM
影响因子：
37.8
作者：
Hayashi, T;Boyko, EJ;Fujimoto, WY
通讯作者：
Fujimoto, WY
影响因子：
24
作者：
Chandra, Alvin;Neeland, Ian J.;Turer, Aslan T.
通讯作者：
Turer, Aslan T.
DOI：
10.1161/hypertensionaha.110.163147
发表时间：
2011-04
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Adachi T;Sert-Kuniyoshi FH;Calvin AD;Singh P;Romero-Corral A;van der Walt C;Davison DE;Bukartyk J;Konecny T;Pusalavidyasagar S;Sierra-Johnson J;Somers VK
通讯作者：
Somers VK
影响因子：
7.7
作者：
Goodpaster, BH;Kelley, DE;Thaete, FL
通讯作者：
Thaete, FL