Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma.
Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma.
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巨噬细胞迁移抑制因子的上调促进肿瘤转移并与胰腺导管腺癌的不良预后相关
DOI：
10.3892/or.2018.6703
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发表时间：
2018-11
期刊：
影响因子：
4.2
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Wang D;Wang R;Huang A;Fang Z;Wang K;He M;Xia JT;Li W
巨噬细胞迁移抑制因子（Macrophage migration inhibitory factor， MIF）是一种促炎性细胞因子，在肿瘤中起重要作用。在包括胰腺癌在内的许多人类癌症类型中经常观察到MIF过表达。然而，MIF在胰腺导管腺癌（PDAC）中的预后价值和功能尚未完全阐明。在本研究中，与邻近正常组织相比，观察到PDAC组织中MIF表达上调。此外，MIF过表达与PDAC患者的低生存率显著相关。多因素Cox回归分析证实MIF是不良生存的独立危险因素。功能分析表明，与对照细胞相比，MIF敲低可显著抑制体外胰腺癌细胞的增殖和侵袭。此外，机制研究表明，沉默MIF可抑制AKT丝氨酸/苏氨酸激酶和细胞外信号调节激酶的激活，抑制细胞周期蛋白D1和基质金属蛋白酶-2的表达，从而抑制肿瘤的增殖和侵袭。这些结果强调了MIF过表达在PDAC侵袭性中的重要性，并表明MIF可能是胰腺癌的潜在治疗靶点。
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that serves important roles in cancer. MIF overexpression is frequently observed in numerous human cancer types, including pancreatic carcinoma. However, the prognostic value and function of MIF in pancreatic ductal adenocarcinoma (PDAC) have not been fully elucidated. In the present study, upregulation of MIF expression in PDAC tissue compared with adjacent normal tissue was observed. Furthermore, MIF overexpression was identified to be significantly associated with poor survival rates in patients with PDAC. Multivariate Cox regression analysis confirmed that MIF was an independent risk factor for poor survival. Functional analyses demonstrated that MIF knockdown significantly inhibited the proliferation and invasion of pancreatic cancer cells in vitro compared with control cells. IN addition, mechanistic investigations revealed that silencing MIF leads to inhibition of AKT serine/threonine kinase and extracellular-signal-regulated kinase activation, and suppression of cyclin D1 and matrix metalloproteinase-2 expression, which may suppress tumor proliferation and invasion. These results highlight the importance of MIF overexpression in PDAC aggressiveness, and indicate that MIF may be a potential therapeutic target for pancreatic cancer.
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DOI：
10.1007/978-3-0348-0837-8_6
发表时间：
2014-01-01
期刊：
INFLAMMATION AND CANCER
影响因子：
--
作者：
Hausmann, Simone;Kong, Bo;Friess, Helmut
通讯作者：
Friess, Helmut
巨噬细胞迁移抑制因子参与PI3K/AKT信号传导，并且是转移性黑色素瘤的预后因素。
影响因子：
3.8
作者：
Oliveira CS;de Bock CE;Molloy TJ;Sadeqzadeh E;Geng XY;Hersey P;Zhang XD;Thorne RF
通讯作者：
Thorne RF
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
影响因子：
3.1
作者：
Liu, Jun;Ben, Qi-Wen;Yuan, Yao-Zong
通讯作者：
Yuan, Yao-Zong
小干扰 RNA (siRNA) 介导的巨噬细胞迁移抑制因子 (MIF) 敲低可抑制细胞周期蛋白 D1 表达和肝细胞癌细胞增殖
影响因子：
--
作者：
Huang XH;Jian WH;Wu ZF;Zhao J;Wang H;Li W;Xia JT
通讯作者：
Xia JT