Endoplasmic Reticulum Stress: Relevance and Therapeutics in Central Nervous System Diseases
Endoplasmic Reticulum Stress: Relevance and Therapeutics in Central Nervous System Diseases
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内质网应激：中枢神经系统疾病的相关性和治疗方法
DOI：
10.1007/s12035-014-8813-7
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发表时间：
2014-07
影响因子：
5.1
通讯作者：
Xiao Jian
中科院分区：
文献类型：
--
作者：
Zhang Hong-Yu;Wang Zhou-guang;Lu Xiang-Hong;Kong Xiao-Xia;Wu Fen-Zan;Lin Li;Tan Xiaohua;Ye Li-Bing;Xiao Jian
Endoplasmic reticulum (ER) stress plays an important role in a range of neurological disorders, such as neurodegenation diseases, cerebral ischemia, spinal cord injury, sclerosis, and diabetic neuropathy. Protein misfolding and accumulation in the ER lumen initiate unfolded protein response in energy-starved neurons which are relevant to toxic effects. In neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, ER dysfunction is well recognized, but the mechanisms remain unclear. In stroke and ischemia, spinal cord injury, and amyotrophic lateral sclerosis, chronic activation of ER stress is considered as main pathogeny which causes neuronal disorders. By targeting components of these ER signaling responses, to explore clinical treatment strategies or new drugs in CNS neurological diseases might become possible and valuable in the future.
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影响因子：
5.5
作者：
Jinxia Zhou;Hao-Bo Zhang;Yue Huang;Yi He;Yan Zheng;John P. Anderson;W. Gai;Zhijuan Liang;Yong Wang;Xingmei Ren;Qi Wang;Xiao-Li Gong;Jian Yang;Xuan Wang;G. Halliday;Xiao-min Wang
通讯作者：
Jinxia Zhou;Hao-Bo Zhang;Yue Huang;Yi He;Yan Zheng;John P. Anderson;W. Gai;Zhijuan Liang;Yong Wang;Xingmei Ren;Qi Wang;Xiao-Li Gong;Jian Yang;Xuan Wang;G. Halliday;Xiao-min Wang
影响因子：
4.2
作者：
Osada, Nobuhiro;Kosuge, Yasuhiro;Ito, Yoshihisa
通讯作者：
Ito, Yoshihisa
影响因子：
9
作者：
通讯作者：
--
影响因子：
12.4
作者：
通讯作者：
--
影响因子：
1.9
作者：
Krishnamoorthy Srinivasan;S. Sharma
通讯作者：
Krishnamoorthy Srinivasan;S. Sharma