A Novel Campylobacter jejuniTwo-Component Regulatory System Important for Temperature-Dependent Growth and Colonization
A Novel Campylobacter jejuniTwo-Component Regulatory System Important for Temperature-Dependent Growth and Colonization
复制标题
一种新型空肠弯曲杆菌双组分调节系统，对温度依赖性生长和定殖很重要
DOI：
10.1128/jb.181.10.3298-3302.1999
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发表时间：
1999
影响因子：
3.2
通讯作者：
J. Ketley
中科院分区：
文献类型：
--
作者：
Ana M. Brás;Shimonti Chatterjee;B. Wren;D. Newell;J. Ketley
摘要空肠弯曲菌在家畜和野生动物的肠道内定植，是人类肠道疾病的常见病原。我们确定了一个双组分的调节系统，指定的RacR-RacS（降低殖民能力）系统，这是参与温度依赖性信号通路。反应调节基因racR的突变降低了该生物体在鸡肠道定植的能力，并导致其蛋白质谱和生长特性的温度依赖性变化。
ABSTRACT Campylobacter jejuni colonizes the intestines of domestic and wild animals and is a common cause of human diarrheal disease. We identified a two-component regulatory system, designated the RacR-RacS (reduced ability to colonize) system, that is involved in a temperature-dependent signalling pathway. A mutation of the response regulator gene racR reduced the organism’s ability to colonize the chicken intestinal tract and resulted in temperature-dependent changes in its protein profile and growth characteristics.
影响因子：
2.9
作者：
FOSTER, LM;LANDRY, C;CAMPAGNONI, AT
通讯作者：
CAMPAGNONI, AT
DOI：
10.1073/pnas.89.21.10079
发表时间：
1992-11-01
影响因子：
11.1
作者：
ARANDA, CMA;SWANSON, JA;MILLER, SI
通讯作者：
MILLER, SI