Cell death-based treatment of lung adenocarcinoma.
Cell death-based treatment of lung adenocarcinoma.
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DOI：
10.1038/s41419-017-0063-y
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发表时间：
2018-01-25
影响因子：
9
通讯作者：
Zhivotovsky B
中科院分区：
文献类型：
--
作者：
Denisenko TV;Budkevich IN;Zhivotovsky B
最常见的肺癌类型是腺癌 (ADC)，约占所有肺癌病例的 40%。尽管在了解这种疾病的发病机制以及开发新的治疗方法方面取得了成就，但不幸的是，肺 ADC 仍然是最具侵袭性和快速致命的肿瘤类型之一，总体生存期不到 5 年。肺 ADC 通常在涉及播散性转移性肿瘤的晚期阶段被诊断出来。这对于成功开发癌症治疗新方法尤为重要。肺 ADC 对传统放疗和化疗的高耐药性对治疗效果提出了重大挑战。在这里，我们讨论了了解驱动肿瘤进展的分子途径以及肺 ADC 相关靶向治疗的最新进展。此外，还分析了不同治疗策略诱导的细胞死亡机制及其对治疗抵抗的贡献。重点是克服耐药性的方法，以改善未来的治疗决策。
The most common type of lung cancer is adenocarcinoma (ADC), comprising around 40% of all lung cancer cases. In spite of achievements in understanding the pathogenesis of this disease and the development of new approaches in its treatment, unfortunately, lung ADC is still one of the most aggressive and rapidly fatal tumor types with overall survival less than 5 years. Lung ADC is often diagnosed at advanced stages involving disseminated metastatic tumors. This is particularly important for the successful development of new approaches in cancer therapy. The high resistance of lung ADC to conventional radiotherapies and chemotherapies represents a major challenge for treatment effectiveness. Here we discuss recent advances in understanding the molecular pathways driving tumor progression and related targeted therapies in lung ADCs. In addition, the cell death mechanisms induced by different treatment strategies and their contribution to therapy resistance are analyzed. The focus is on approaches to overcoming drug resistance in order to improve future treatment decisions.
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肿瘤免疫学和肺癌免疫治疗的趋势和进展。
DOI：
10.1186/s13046-016-0439-3
发表时间：
2016-09-29
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Aldarouish M;Wang C
通讯作者：
Wang C
影响因子：
--
作者：
Chen, Yan-bin;Mu, Chuan-Yong;Huang, Jian-An
通讯作者：
Huang, Jian-An
影响因子：
4
作者：
Alamgeer, Muhammad;Ganju, Vinod;Watkins, D. Neil
通讯作者：
Watkins, D. Neil
影响因子：
5.7
作者：
Christensen, James G.;Zou, Helen Y.;Los, Gerrit
通讯作者：
Los, Gerrit
DOI：
10.1097/jto.0000000000000551
发表时间：
2015-07
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Carbone DP;Gandara DR;Antonia SJ;Zielinski C;Paz-Ares L
通讯作者：
Paz-Ares L