Adipose tissue microenvironments during aging: Effects on stimulated lipolysis.
Adipose tissue microenvironments during aging: Effects on stimulated lipolysis.
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DOI：
10.1016/j.bbalip.2022.159118
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Camell CD
中科院分区：
文献类型：
--
作者：
Camell CD
脂肪组织是营养感知、能量储存和维持代谢健康的关键器官。脂肪组织稳态的失败会导致肥胖或衰老期间出现的代谢疾病。局部代谢过程由相互作用的微环境协调，微环境构成脂肪组织的复杂性和异质性。儿茶酚胺诱导的脂解是脂肪细胞中的一个关键途径，在刺激后驱动储存的甘油三酯作为游离脂肪酸释放，在衰老过程中受损。该途径的损伤与未能维持健康的体重、体温或产生免疫应答有关。沿着衰老脂肪细胞的损伤，衰老与脂肪组织内炎症的积累、免疫细胞活化以及神经和淋巴系统功能障碍的增加有关。这些微环境共同支持在代谢稳态条件下刺激脂解和游离脂肪酸转运的启动。然而，在衰老过程中，这些细胞系统的缺陷导致刺激脂解的能力降低。本次审查将集中在免疫，神经和淋巴系统如何在组织内稳态相互作用，审查与衰老受损的领域，并讨论目前尚不清楚的研究领域。
Adipose tissue is a critical organ for nutrient sensing, energy storage and maintaining metabolic health. The failure of adipose tissue homeostasis leads to metabolic disease that is seen during obesity or aging. Local metabolic processes are coordinated by interacting microenvironments that make up the complexity and heterogeneity of the adipose tissue. Catecholamine-induced lipolysis, a critical pathway in adipocytes that drives the release of stored triglyceride as free fatty acid after stimulation, is impaired during aging. The impairment of this pathway is associated with a failure to maintain a healthy body weight, body-temperature or mount an immune response. Along with impairments in aged adipocytes, aging is associated with an accumulation of inflammation, immune cell activation, and increased dysfunction in the nervous and lymphatic systems within the adipose tissue. Together these microenvironments support the initiation of stimulated lipolysis and the transport of free fatty acid under conditions of metabolic homeostasis. However, during aging, the defects in these cellular systems result in a reduction in ability to stimulate lipolysis. This review will focus on how the immune, nervous and lymphatic systems interact during tissue homeostasis, review areas that are impaired with aging and discuss areas of research that are currently unclear.
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影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
4.3
作者：
Cinti S
通讯作者：
Cinti S
巨噬细胞的局部扩散有助于与肥胖相关的脂肪组织炎症。
影响因子：
29
作者：
Amano SU;Cohen JL;Vangala P;Tencerova M;Nicoloro SM;Yawe JC;Shen Y;Czech MP;Aouadi M
通讯作者：
Aouadi M
DOI：
10.1152/ajpheart.00467.2015
发表时间：
2015-12-15
影响因子：
4.8
作者：
Chakraborty, Sanjukta;Zawieja, Scott D.;Muthuchamy, Mariappan
通讯作者：
Muthuchamy, Mariappan
影响因子：
7.8
作者：
Camell C;Goldberg E;Dixit VD
通讯作者：
Dixit VD