Metabolic Interactions in the Tumor Microenvironment.
Metabolic Interactions in the Tumor Microenvironment.
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DOI：
10.1016/j.tcb.2017.06.003
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发表时间：
2017-11
影响因子：
19
通讯作者：
Kimmelman AC
中科院分区：
文献类型：
--
作者：
Lyssiotis CA;Kimmelman AC
肿瘤是动态的假器官，包含许多相互作用以产生独特生理学的细胞类型。在这个网络中，恶性细胞遇到许多挑战，并相应地重新连接它们的代谢特性。这种变化可以自主经历和执行，也可以通过与肿瘤中其他细胞的相互作用来实现。这篇综述的重点是肿瘤微环境的重塑，导致受代谢影响和塑造的病理生理相互作用。它们包括共生营养共享、营养竞争和代谢物作为信号分子的作用。这种过程的例子在正常的生物体生理学中比比皆是，并且这种异细胞代谢相互作用被重新用于支持肿瘤代谢和生长。这些过程的重要性和普遍性才刚刚开始被认识到，对它们在肿瘤发展和进展中作用的深入了解正被用于设计新的药物靶点和癌症疗法。
Tumors are dynamic pseudo-organs that contain numerous cell types interacting to create unique physiology. Within this network, the malignant cells encounter many challenges and rewire their metabolic properties accordingly. Such changes can be experienced and executed autonomously or through interaction with other cells in the tumor. The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism. They include symbiotic nutrient sharing, nutrient competition, and the role of metabolites as signaling molecules. Examples of such processes abound in normal organismal physiology, and such heterocelluar metabolic interactions are repurposed to support tumor metabolism and growth. The importance and ubiquity of these processes is just beginning to be realized, and insights into their role in tumor development and progression are being used to design new drug targets and cancer therapies.
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癌细胞对葡萄糖限制和双胍类药物敏感性的代谢决定因素。
影响因子：
64.8
作者：
Birsoy, Kivanc;Possemato, Richard;Lorbeer, Franziska K.;Bayraktar, Erol C.;Thiru, Prathapan;Yucel, Burcu;Wang, Tim;Chen, Walter W.;Clish, Clary B.;Sabatini, David M.
通讯作者：
Sabatini, David M.
影响因子：
4.3
作者：
Draoui N;Feron O
通讯作者：
Feron O
影响因子：
5.9
作者：
Balaban S;Shearer RF;Lee LS;van Geldermalsen M;Schreuder M;Shtein HC;Cairns R;Thomas KC;Fazakerley DJ;Grewal T;Holst J;Saunders DN;Hoy AJ
通讯作者：
Hoy AJ
影响因子：
29.4
作者：
DuFort CC;DelGiorno KE;Hingorani SR
通讯作者：
Hingorani SR
DOI：
10.1158/1541-7786.mcr-12-0437-t
发表时间：
2013-06
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Chaudhri VK;Salzler GG;Dick SA;Buckman MS;Sordella R;Karoly ED;Mohney R;Stiles BM;Elemento O;Altorki NK;McGraw TE
通讯作者：
McGraw TE