Co-Localization of Gastrointestinal Stromal Tumors (GIST) and Peritoneal Mesothelioma: A Case Series.
Co-Localization of Gastrointestinal Stromal Tumors (GIST) and Peritoneal Mesothelioma: A Case Series.
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DOI：
10.1245/s10434-022-12211-x
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发表时间：
2022-11
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
胃肠道间质瘤（GIST）与其他癌症的风险增加有关。在这项研究中，同步GIST和腹膜间皮瘤（PM）的特点，以评估这两种癌症之间的关系。对2010年7月至2021年6月期间诊断为GIST和PM的患者进行了回顾性病历审查。对患者人口统计学、既往肿瘤史、术中报告、横断面成像、腹膜癌指数（PCI）评分、体细胞下一代测序（NGS）分析和组织学进行了审查。在2010年7月至2021年6月接受原发性GIST切除术的137例患者中，发现8例（5.8%）患有同步PM，4例（50%）患有其他癌症和/或良性肿瘤。5例（62.5%）为男性，诊断GIST时的中位年龄为57岁（范围：45-76岁）。75%的GIST起源于胃。在这8名患者中，1名患者患有同步性恶性间皮瘤（MM），其余患者患有分化良好的乳头状间皮瘤（WESTERN），主要位于原发性GIST区域（89%）。WESTERN患者的中位PCI评分为2分。GIST的NGS显示致癌KIT外显子11（62.5%）、PDGFRA D842 V（25%）或SDH（12.5%）突变，而MM的NGS显示BAP 1和PBRM 1改变。在该系列中，每17例接受切除术的GIST患者中就有1例患有PM，如果将这两种疾病视为独立事件，则PM显著高于预期。我们的研究结果表明，GIST和PM的同步共现是一个认识不足的发现，这表明可能的关系，值得进一步研究。
Gastrointestinal stromal tumor (GIST) is associated with increased risk of additional cancers. In this study, synchronous GIST, and peritoneal mesothelioma (PM) were characterized to evaluate the relationship between these two cancers. A retrospective chart review was conducted for patients diagnosed with both GIST and PM between July 2010 and June 2021. Patient demographics, past tumor history, intraoperative reports, cross-sectional imaging, peritoneal cancer index (PCI) scoring, somatic next-generation sequencing (NGS) analysis, and histology were reviewed. Of 137 patients who underwent primary GIST resection from July 2010 to June 2021, 8 (5.8%) were found to have synchronous PM, and 4 patients (50%) had additional cancers and/or benign tumors. Five (62.5%) were male, and the median age at GIST diagnosis was 57 years (range: 45–76). Seventy-five percent of GISTs originated from the stomach. Of the eight patients, one patient had synchronous malignant mesothelioma (MM), and the remaining had well-differentiated papillary mesothelioma (WDPM), which were primarily located in the region of the primary GIST (89%). The median PCI score was 2 in the WDPM patients. NGS of GIST revealed oncogenic KIT exon 11 (62.5%), PDGFRA D842V (25%), or SDH (12.5%) mutations, while NGS of the MM revealed BAP1 and PBRM1 alterations. One in 17 GIST patients undergoing resection in this series have PM, which is significantly higher than expected if these two diseases were considered as independent events. Our results indicate that synchronous co-occurrence of GIST and PM is an underrecognized finding, suggesting a possible relationship that deserves further investigation.
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影响因子：
6.2
作者：
Murphy JD;Ma GL;Baumgartner JM;Madlensky L;Burgoyne AM;Tang CM;Martinez ME;Sicklick JK
通讯作者：
Sicklick JK
影响因子：
15.3
作者：
Ferreira, Sheila S.;Werutsky, Gustavo;Garicochea, Bernardo
通讯作者：
Garicochea, Bernardo
影响因子：
50.5
作者：
Pandurengan, R. K.;Dumont, A. G.;Trent, J. C.
通讯作者：
Trent, J. C.
影响因子：
2.3
作者：
Kim, Moonsik;Kim, Hyun-Soo
通讯作者：
Kim, Hyun-Soo
影响因子：
5.6
作者：
Malpica, Anais;Sant'Ambrogio, Sara;Silva, Elvio G.
通讯作者：
Silva, Elvio G.