Genetic and familial factors in essential hypertension and related traits
Genetic and familial factors in essential hypertension and related traits
复制标题
原发性高血压的遗传和家族因素及相关特征
DOI：
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
R. Siervogel
中科院分区：
文献类型：
--
作者：
R. Siervogel
The health significance of essential hypertension “high blood pressure of undefined origin” is well established. It is a major factor contributing to coronary heart disease, stroke, and kidney failure. It directly affects about one in five Americans. Factors which are known to be associated with blood pressure include: body composition as it relates to overall mass and fat mass; physiological variables involving the sympathetic and parasympathetic nervous systems; biochemical variables such as renin, aldosterone, kallikrein, lipids, and lipoproteins, etc.; environmental variables such as sodium intake, heavy metals, and noise; and psychological variables involving personality type and mental stress.
There is a definite, well-established genetic involvement in hypertension, but specific genetic mechanisms remain a mystery. Familial aggregation occurs for many of the associated traits listed above. For some, specific polymorphic major genes have been identified, but for others genetic factors are unidentified. Essential hypertension is undoubtedly a heterogeneous group of diseases with the common end result of elevated blood pressure. Because of its health significance, there is considerable interest in identifying genetic mechanisms resulting in essential hypertension. One area that currently shows some potential for the identification of a specific genetic mechanism is related to the transmembrane transport of sodium and potassium cations.
血浆多巴胺-β-羟化酶热稳定性的家族研究。
影响因子：
9.8
作者：
Dunnette,J;Weinshilboum,R
通讯作者：
Weinshilboum,R
儿童血压及其与血脂和脂蛋白的关系：来自 Fels 纵向研究的横断面数据。
影响因子：
5.1
作者：
Siervogel,RM;Roche,AF;Morris,JG;Glueck,CJ
通讯作者：
Glueck,CJ