Autophagy in the physiological endometrium and cancer.
Autophagy in the physiological endometrium and cancer.
复制标题
DOI：
10.1080/15548627.2020.1752548
复制
发表时间：
2021-05
期刊：
影响因子：
13.3
通讯作者：
Llobet-Navàs D
中科院分区：
文献类型：
--
作者：
Devis-Jauregui L;Eritja N;Davis ML;Matias-Guiu X;Llobet-Navàs D
自噬是一种高度保守的分解代谢过程，也是降解长寿命蛋白质和细胞质细胞器的主要途径。越来越多的证据表明，自噬是一种不可或缺的生物学功能，有助于维持正常的组织动态平衡和新陈代谢健康，当自噬发生变化时，也可能导致正常细胞功能的严重后果。最近积累的数据表明，自噬在人类子宫内膜的各种生理和病理生理条件下发挥着关键作用，子宫内膜是人体内最熟练的自我再生组织之一，也是胎盘物种生殖功能的工具参与者。目前的综述重点介绍了关于正常和癌变子宫内膜组织中自噬过程的最新发现。目前的研究工作，旨在治疗性地利用自噬和所使用的方法学方法进行了讨论。缩写：3-MA：3-甲基腺嘌呤；ACACA(乙酰辅酶A羧基酶α)；AICAR：5-氨基咪唑-4-羧基核苷；AKT：AKT丝氨酸/苏氨酸激酶；AMPK：AMP激活的蛋白激酶；ATG：自噬相关；ATG12：自噬相关12；ATG16L1：自噬相关16样1；ATG3：自噬相关3；ATG4C：自噬相关的4C半胱氨酸多肽酶；ATG5：自噬相关的5；ATG7：自噬相关的7；ATG9：自噬相关的9；BaF：bafmycin A1；Bax：B2X，调节器；CLB2：自噬相关的3；ATG5：自噬相关的4C半胱氨酸肽酶；ATG5：自噬相关的5；ATG7：自噬相关的7；ATG9：自噬相关的9；BaF A1：bafmycin A1；Bax：BCL2相关的调节因子；CLB2：自噬相关的调节因子；CNB1：凋亡：1；CACNA1D：钙电压门控通道亚单位α1 D；CASP3：caspase 3；CASP7：caspase 7；CASP8：caspase 8；CASP9：caspase 9；CD44：CD44分子(印度血型)；CDH1：钙粘蛋白1；CDKN1A：细胞周期蛋白依赖性激酶抑制因子1A；CDKN2A：细胞周期蛋白依赖性激酶抑制因子2A；CMA：伴侣介导的自噬；CQ：氯喹；CTNNB1：连环素β1；DDIT3：DNA损伤诱导转录本3；EC：子宫内膜癌；EGFR：表皮生长因子受体；EH：子宫内膜增生症；IF4E：真核细胞起始因子4E；EPHB2/ERK：Eph B2受体；ER：内质网；ERBB2：ER-b2受体酪氨酸激酶2；ERVW-1：内源性逆转录病毒W组成员1，包膜；ESR1：雌激素受体1；FSH：卵泡刺激素；GCG/GLP1：胰高血糖素；GFP：绿色荧光蛋白；GIP：胃抑制多肽；GLP1R：胰高血糖素样肽-1受体；GLS：谷氨酰胺酶；H_2AX：H_2A.X变异组蛋白；HIF1a：缺氧诱导因子1α；HMGB1：高迁移率组盒1；HOTAIR：Hox转录反义RNA；HSPA5：热休克蛋白A家族(HSP70)蛋白家族成员5；HSPA8：热休克蛋白家族(HSP70)成员8；IGF1：胰岛素样生长因子1；IL27：白介素27；INS：胰岛素；ISL：异甘草素；KRAS：KRAS原癌基因，GTPase；LAMP2：溶酶体相关膜蛋白2；lncRNA：长非编码RNA；MAP1LC3A/LC3A：微管相关蛋白1轻链3α；MAP1LC3B/LC3B：微管相关蛋白1轻链3β；MAPK8：丝裂原活化蛋白激酶8；MAPK9：丝裂原活化蛋白激酶9；MPA：甲孕酮醋酸酯；OR：雷帕霉素机械靶点；mTORC1：雷帕霉素复合体机械靶点；mTORC2：雷帕霉素复合体机械靶点2；MYCBP：MYC结合蛋白；MAPK8：丝裂原活化蛋白激酶8；MAPK9：丝裂原活化蛋白激酶9；甲孕酮醋酸酯；OR：雷帕霉素机械靶点；mORC1：雷帕霉素复合体机械靶点1；MYCBP：MYC结合蛋白；NFE2L2：核因子，红系2样2；NFKB：核因子kappa B；NFKBIA：NFkB抑制因子α；NK：自然杀伤分子；NR5A1：核受体亚家族A组成员1；PARP1：聚(ADP-核糖)聚合酶1；PAX2：配对盒2；PDK1：丙酮酸脱氢酶1；PDX：患者来源的异种移植；PIK3C3/Vps34：磷脂酰肌醇3-激酶催化亚单位3型；PIK3CA：磷脂酰肌醇-4，5-双磷酸-3-激酶催化亚单位；P3R1：磷脂酰肌醇-3-调节亚基1；PIKfyve：磷脂酰肌醇激酶，FYVE-型锌；PPD：异种异种移植；PIK3C3/Vps34：磷脂酰肌醇-3-激酶催化亚单位3型；PIK3CA：磷脂酰肌醇-4，5-双磷酸-3-激酶催化亚单位；P3R1：磷脂酰肌醇-3-调节亚单位1；PIKfyve：磷酸肌醇激酶，FYVE-型锌指；PPD：异种异种移植；PIK3C3/Vps34：磷脂酰肌醇-3-激酶催化亚单位；PIK3CA：磷脂酰肌醇-4，5-双磷酸-磷酸肌醇3-催化亚单位；PIK3R1：磷脂酰肌醇-3-调节亚单位1；PIKfyve：磷酸肌醇激酶，FYVE-型锌指；PPD：含丙二醇型异种异种移植；PIK3C3/Vps34：磷脂酰肌醇-3-激酶催化亚单位；PIKK3CA：磷脂酰肌醇-4，5-双磷酸-磷酸肌醇-3-催化亚单位；PIKR1：PROM1/CD133：重要蛋白1；PtdIns3K：III类磷脂酰肌醇3-激酶；PtdIns3P：磷脂酰肌醇-3-磷酸；PTEN：磷酸酶和张力蛋白同源物；RB1CC1/FIP200：Rb1可诱导卷曲线圈1；RFP：红色荧光蛋白；RPS6KB1/S6K1：核糖体蛋白S6激酶B1；RSV：白藜芦醇；SGK1：血清/糖皮质激素调节的激酶1；SGK3：血清/糖皮质激素调节的激酶家族成员3；SIRT：sirtuin；SLS：结石样结构；Smad2：Smad家族成员；SMAD3：Smad家族成员3；SQSTM1：转录激活因子1；TALEN：核糖体蛋白S6激酶B1；RSV：白藜芦醇；SGK1：血清/糖皮质激素调节的激酶1；SGK3：血清/糖皮质激素调节的激酶家族成员3；SIRT：sirtuin；SLS：结石样结构；Smad2：Smad家族成员；SMAD3：Smad家族成员3；SQSTM1：转录激活因子1；TALEN：核糖体蛋白S6激酶B1；RSV：白藜芦醇；SGK1：血清/糖皮质激素调节的激酶1；SGK3：血清/糖皮质激素调节的激酶家族成员3；SIRT：sirtuin；SLS：结石样结构；Smad2：Smad家族成员；SMAD3：Smad家族成员3；SQSTM1：转录激活因子1；TALEN：核糖体蛋白S6激酶B1；RSV：白藜芦醇；SGK1：血清/糖皮质激素调节的激酶1；SGK3：血清/糖皮质激素调节的激酶家族成员3；SIRT：sirtuin；SLS：结石样结构；Smad2：Smad家族成员；SMAD3：TP53：肿瘤蛋白P53；TRIB3：摩擦假蛋白3；ULK1：UNC-51样自噬激活蛋白1；ULK4：UNC-51样蛋白4；VEGFA：血管内皮生长因子A；WIPI2：WD重复结构域，磷酸肌醇相互作用2；XBP1：X-box结合蛋白1；ZFYVE1：锌指FYVE结构域包含1。
Autophagy is a highly conserved catabolic process and a major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles. An increasing body of evidence has unveiled autophagy as an indispensable biological function that helps to maintain normal tissue homeostasis and metabolic fitness that can also lead to severe consequences for the normal cellular functioning when altered. Recent accumulating data point to autophagy as a key player in a wide variety of physiological and pathophysiological conditions in the human endometrium, one of the most proficient self-regenerating tissues in the human body and an instrumental player in placental species reproductive function. The current review highlights the most recent findings regarding the process of autophagy in the normal and cancerous endometrial tissue. Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed. Abbreviations: 3-MA: 3-methyladenine; ACACA (acetyl-CoA carboxylase alpha); AICAR: 5-aminoimidazole-4-carboximide riboside; AKT: AKT serine/threonine kinase; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG12: autophagy related 12; ATG16L1: autophagy related 16 like 1; ATG3: autophagy related 3; ATG4C: autophagy related 4C cysteine peptidase; ATG5: autophagy related 5; ATG7: autophagy related 7; ATG9: autophagy related 9; Baf A1: bafilomycin A1; BAX: BCL2 associated X, apoptosis regulator; BCL2: BCL2 apoptosis regulator; BECN1: beclin 1; CACNA1D: calcium voltage-gated channel subunit alpha1 D; CASP3: caspase 3; CASP7: caspase 7; CASP8: caspase 8; CASP9: caspase 9; CD44: CD44 molecule (Indian blood group); CDH1: cadherin 1; CDKN1A: cyclin dependent kinase inhibitor 1A; CDKN2A: cyclin dependent kinase inhibitor 2A; CMA: chaperone-mediated autophagy; CQ: chloroquine; CTNNB1: catenin beta 1; DDIT3: DNA damage inducible transcript 3; EC: endometrial cancer; EGFR: epidermal growth factor receptor; EH: endometrial hyperplasia; EIF4E: eukaryotic translation initiation factor 4E; EPHB2/ERK: EPH receptor B2; ER: endoplasmic reticulum; ERBB2: er-b2 receptor tyrosine kinase 2; ERVW-1: endogenous retrovirus group W member 1, envelope; ESR1: estrogen receptor 1; FSH: follicle-stimulating hormone; GCG/GLP1: glucagon; GFP: green fluorescent protein; GIP: gastric inhibitory polypeptide; GLP1R: glucagon-like peptide-1 receptor; GLS: glutaminase; H2AX: H2A.X variant histone; HIF1A: hypoxia inducible factor 1 alpha; HMGB1: high mobility group box 1; HOTAIR: HOX transcript antisense RNA; HSPA5: heat shock protein family A (HSP70) member 5; HSPA8: heat shock protein family A (HSP70) member 8; IGF1: insulin like growth factor 1; IL27: interleukin 27; INS: insulin; ISL: isoliquiritigenin; KRAS: KRAS proto-oncogene, GTPase; LAMP2: lysosomal-associated membrane protein 2; lncRNA: long-non-coding RNA; MAP1LC3A/LC3A: microtubule associated protein 1 light chain 3 alpha; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAPK8: mitogen-activated protein kinase 8; MAPK9: mitogen-activated protein kinase 9; MPA: medroxyprogesterone acetate; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; MTORC2: mechanistic target of rapamycin kinase complex 2; MYCBP: MYC-binding protein; NFE2L2: nuclear factor, erythroid 2 like 2; NFKB: nuclear factor kappa B; NFKBIA: NFKB inhibitor alpha; NK: natural killer; NR5A1: nuclear receptor subfamily 5 group A member 1; PARP1: poly(ADP-ribose) polymerase 1; PAX2: paired box 2; PDK1: pyruvate dehydrogenase kinase 1; PDX: patient-derived xenograft; PIK3C3/Vps34: phosphatidylinositol 3-kinase catalytic subunit type 3; PIK3CA: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; PIK3R1: phosphoinositide-3-kinase regulatory subunit 1; PIKFYVE: phosphoinositide kinase, FYVE-type zinc finger containing; PPD: protopanaxadiol; PRKCD: protein kinase C delta; PROM1/CD133: prominin 1; PtdIns3K: class III phosphatidylinositol 3-kinase; PtdIns3P: phosphatidylinositol-3-phosphate; PTEN: phosphatase and tensin homolog; RB1CC1/FIP200: RB1 inducible coiled-coil 1; RFP: red fluorescent protein; RPS6KB1/S6K1: ribosomal protein S6 kinase B1; RSV: resveratrol; SGK1: serum/glucocorticoid regulated kinase 1; SGK3: serum/glucocorticoid regulated kinase family member 3; SIRT: sirtuin; SLS: stone-like structures; SMAD2: SMAD family member 2; SMAD3: SMAD family member 3; SQSTM1: sequestosome 1; TALEN: transcription activator-like effector nuclease; TGFBR2: transforming growth factor beta receptor 2; TP53: tumor protein p53; TRIB3: tribbles pseudokinase 3; ULK1: unc-51 like autophagy activating kinase 1; ULK4: unc-51 like kinase 4; VEGFA: vascular endothelial growth factor A; WIPI2: WD repeat domain, phosphoinositide interacting 2; XBP1: X-box binding protein 1; ZFYVE1: zinc finger FYVE domain containing 1.
登录
查看更多内容
影响因子：
5.6
作者：
De U;Son JY;Sachan R;Park YJ;Kang D;Yoon K;Lee BM;Kim IS;Moon HR;Kim HS
通讯作者：
Kim HS
影响因子：
158.5
作者：
Druker, Brian J.;Guilhot, Francois;Larson, Richard A.
通讯作者：
Larson, Richard A.
影响因子：
4.8
作者：
Dolcet, Xavier;Llobet, David;Matias-Guiu, Xavier
通讯作者：
Matias-Guiu, Xavier
影响因子：
2.9
作者：
Avagliano, Laura;Terraneo, Laura;Marconi, Anna Maria
通讯作者：
Marconi, Anna Maria
影响因子：
4.7
作者：
Befani, Christina D.;Vlachostergios, Panagiotis J.;Liakos, Panagiotis
通讯作者：
Liakos, Panagiotis