Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury.
Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury.
复制标题
DOI：
10.3164/jcbn.2008013
复制
发表时间：
2008-03
影响因子：
2.4
通讯作者：
McCurry KR
中科院分区：
文献类型：
--
作者：
Nakao A;Kaczorowski DJ;Sugimoto R;Billiar TR;McCurry KR
肠缺血/再灌注（I/R）损伤经常发生在各种临床环境中，包括肠系膜动脉闭塞、腹部外科手术、创伤、休克和小肠移植，并且与大量的发病率和死亡率相关。虽然肠I/R损伤发病机制的确切机制尚未完全阐明，但一般认为，多形核中性粒细胞、促炎细胞因子和氧化应激环境中产生的介质（如活性氧（ROS））发挥重要作用。血红素加氧酶（HO）是限速酶，催化血红素降解为等摩尔量的胆绿素和一氧化碳（CO），同时释放中心铁。HO-1、胆绿素和CO的诱导型已被证明具有广泛的内源性抗炎活性，并提供针对肠I/R损伤的保护。此外，最近的观察表明，外源性HO-1的表达，以及外源性管理的CO和胆绿素，具有强有力的细胞保护作用，肠I/R损伤，以及。在这里，我们总结了目前可用的数据HO系统在预防肠I/R损伤的作用。
Intestinal ischemia/reperfusion (I/R) injury occurs frequently in a variety of clinical settings, including mesenteric artery occlusion, abdominal aneurism surgery, trauma, shock, and small intestinal transplantation, and is associated with substantial morbidity and mortality. Although the exact mechanisms involved in the pathogenesis of intestinal I/R injury have not been fully elucidated, it is generally believed that polymorphonuclear neutrophils, pro-inflammatory cytokines, and mediators generated in the setting of oxidative stress, such as reactive oxygen species (ROS), play important roles. Heme oxygenase (HO) is the rate-limiting enzyme that catalyzes the degradation of heme into equimolar quantities of biliverdin and carbon monoxide (CO), while the central iron is released. An inducible form of HO (HO-1), biliverdin, and CO, have been shown to possess generalized endogenous anti-inflammatory activities and provide protection against intestinal I/R injury. Further, recent observations have demonstrated that exogenous HO-1 expression, as well as exogenously administered CO and biliverdin, have potent cytoprotective effects on intestinal I/R injury as well. Here, we summarize the currently available data regarding the role of the HO system in the prevention intestinal I/R injury.
登录
查看更多内容
影响因子：
6.2
作者：
Coito, AJ;Buelow, R;Kupiec-Weglinski, JW
通讯作者：
Kupiec-Weglinski, JW
影响因子：
2.2
作者：
Attuwaybi, BO;Kozar, RA;Moore, FA
通讯作者：
Moore, FA
影响因子：
2.4
作者：
Ceran, C;Sönmez, K;Kale, N
通讯作者：
Kale, N
影响因子：
6.2
作者：
Cicalese, L;Sileri, P;Reyes, J
通讯作者：
Reyes, J
影响因子：
4.8
作者：
Berberat, PO;Katori, M;Soares, MP
通讯作者：
Soares, MP