mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea.
mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea.
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红斑痤疮的发生需要 mTORC1 介导的血管生成
DOI：
10.3389/fcell.2021.751785
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发表时间：
2021
影响因子：
5.5
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Peng Q;Sha K;Liu Y;Chen M;Xu S;Xie H;Deng Z;Li J
虽然多种证据表明血管生成与酒渣鼻的病理生理有关，但其作用仍存在争议。在这里，我们发现血管生成在酒渣鼻患者和ll37诱导的酒渣鼻样小鼠的皮肤病变中都得到了增强。抑制血管生成可减轻ll37诱导的小鼠酒渣鼻样特征。在机制上，我们发现mTORC1在酒渣鼻患者和ll37诱导的酒渣鼻样小鼠模型的病变皮肤内皮细胞中被激活。抑制mTORC1可减少小鼠血管生成并阻断酒渣鼻的发展。相反，mTORC1的过度激活增加了血管生成并加剧了酒渣鼻样表型。我们的体外实验结果进一步证明，抑制mTORC1信号传导可显著降低ll37诱导的人内皮细胞成管。综上所述，我们的研究结果表明mtorc1介导的血管生成对LL37的反应可能对酒渣鼻的发展至关重要，靶向血管生成可能是一种新的潜在治疗方法。
Although multiple evidences suggest that angiogenesis is associated with the pathophysiology of rosacea, its role is still in debate. Here, we showed that angiogenesis was enhanced in skin lesions of both rosacea patients and LL37-induced rosacea-like mice. Inhibition of angiogenesis alleviated LL37-induced rosacea-like features in mice. Mechanistically, we showed that mTORC1 was activated in the endothelial cells of the lesional skin from rosacea patients and LL37-induced rosacea-like mouse model. Inhibition of mTORC1 decreased angiogenesis and blocked the development of rosacea in mice. On the contrary, hyperactivation of mTORC1 increased angiogenesis and exacerbated rosacea-like phenotypes. Our in vitro results further demonstrated that inhibition of mTORC1 signaling significantly declined LL37-induced tube formation of human endothelial cells. Taken together, our findings revealed that mTORC1-mediated angiogenesis responding to LL37 might be essential for the development of rosacea and targeting angiogenesis might be a novel potential therapy.
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影响因子：
11.5
作者：
Moustafa, Farah A.;Sandoval, Laura F.;Feldman, Steven R.
通讯作者：
Feldman, Steven R.
影响因子：
11.5
作者：
Murphy, James D.;Spalding, Aaron C.;Hamstra, Daniel A.
通讯作者：
Hamstra, Daniel A.
DOI：
10.1038/jidsymp.2011.5
发表时间：
2011-12
影响因子：
--
作者：
Huggenberger, Reto;Detmar, Michael
通讯作者：
Detmar, Michael
DOI：
10.1016/j.jaci.2016.09.052
发表时间：
2017-04
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Naeem AS;Tommasi C;Cole C;Brown SJ;Zhu Y;Way B;Willis Owen SA;Moffatt M;Cookson WO;Harper JI;Di WL;Brown SJ;Reinheckel T;O'Shaughnessy RF
通讯作者：
O'Shaughnessy RF
影响因子：
5.8
作者：
Espona-Fiedler, M.;Soto-Cerrato, V.;Perez-Tomas, R.
通讯作者：
Perez-Tomas, R.