Development of a magnetic nanoparticle susceptibility magnitude imaging array.
Development of a magnetic nanoparticle susceptibility magnitude imaging array.
复制标题
DOI：
10.1088/0031-9155/59/4/1047
复制
发表时间：
2014-02-21
影响因子：
3.5
通讯作者：
Diamond SG
中科院分区：
文献类型：
--
作者：
Ficko BW;Nadar PM;Hoopes PJ;Diamond SG
磁性纳米颗粒（mNPs）在医学中有几种新兴的诊断和治疗应用。本研究探讨了开发mNP成像仪的潜力，满足这些新兴的临床需求，低成本的成像解决方案，使用数字控制的驱动线圈阵列在多频，连续波工作模式和补偿磁通门磁力计。描述了设计方法并开发了数学模型来支持测量和成像。使用原型来证明高达185倍的初级施加磁场的主动补偿、高达2.5cm的深度灵敏度（p < 0.01）以及在5个稀释度上的线性（R2 > 0.98，p <0.001）。系统频率响应显示具有10 nm和40 nm的单磁畴核直径的氧化铁mNP和具有100 nm的流体动力学直径的多畴mNP的可区分的读数。断层扫描图像显示，对于0.5 ml的12.5 mg Fe/ml mNP，在1 cm深度处的对比噪声比为23。一个涉及将mNPs注射到猪肉香肠中的演示显示了在生物系统中使用的潜力。这些结果表明，所提出的mNP成像方法可以潜在地扩展到更大的阵列系统，具有更高的分辨率。
There are several emerging diagnostic and therapeutic applications of magnetic nanoparticles (mNPs) in medicine. This study examines the potential for developing an mNP imager that meets these emerging clinical needs with a low cost imaging solution that uses arrays of digitally controlled drive coils in a multiple-frequency, continuous-wave operating mode and compensated fluxgate magnetometers. The design approach is described and a mathematical model is developed to support measurement and imaging. A prototype is used to demonstrate active compensation of up to 185 times the primary applied magnetic field, depth sensitivity up to 2.5 cm (p < 0.01), and linearity over 5 dilutions (R2 > 0.98, p <0.001). System frequency responses show distinguishable readouts for iron oxide mNPs with single magnetic domain core diameters of 10 nm and 40 nm, and multi-domain mNPs with a hydrodynamic diameter of 100 nm. Tomographic images show a contrast-to-noise ratio of 23 for 0.5 ml of 12.5 mg Fe/ml mNPs at 1 cm depth. A demonstration involving the injection of mNPs into pork sausage shows the potential for use in biological systems. These results indicate that the proposed mNP imaging approach can potentially be extended to a larger array system with higher-resolution.
登录
查看更多内容
影响因子：
10.8
作者：
Fornara, Andrea;Johansson, Petter;Johansson, Christer
通讯作者：
Johansson, Christer
影响因子：
3.8
作者：
Anninga, Bauke;Ahmed, Muneer;Douek, Michael
通讯作者：
Douek, Michael
影响因子：
2.7
作者：
Ferguson RM;Minard KR;Krishnan KM
通讯作者：
Krishnan KM
影响因子：
9
作者：
GILCHRIST, RK;MEDAL, R;TAYLOR, CB
通讯作者：
TAYLOR, CB
影响因子：
3.5
作者：
Adolphi NL;Huber DL;Bryant HC;Monson TC;Fegan DL;Lim J;Trujillo JE;Tessier TE;Lovato DM;Butler KS;Provencio PP;Hathaway HJ;Majetich SA;Larson RS;Flynn ER
通讯作者：
Flynn ER