Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls.
Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls.
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DOI：
10.1111/jcpp.12742
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Franke B
中科院分区：
文献类型：
--
作者：
van Ewijk H;Bralten J;van Duin EDA;Hakobjan M;Buitelaar JK;Heslenfeld DJ;Hoekstra PJ;Hartman C;Hoogman M;Oosterlaan J;Franke B
一氧化氮合酶基因（NOS 1）外显子1f（ex 1f）VNTR是注意力缺陷/多动障碍（ADHD）的已知遗传风险因素，特别是在女性中。NOS 1在神经突生长中起重要作用，因此可能影响大脑发育，特别是白色物质（WM）的微观结构，这是已知的ADHD改变。目前的研究旨在调查NOS 1是否与（女性）ADHD患者和非ADHD患者的WM微结构相关。收集了187名ADHD参与者（33%女性）和103名对照者（50%女性）的扩散张量成像（DTI）扫描，年龄为8-26岁，并确定了NOS 1-ex 1f VNTR基因型。全脑分析进行了分数各向异性（FA）和平均扩散率（MD），以检查NOS 1和WM微结构之间的关联，包括可能的相互作用与性别和诊断。与以前的文献一致，NOS 1-ex 1f与总ADHD和多动-冲动症状相关，但与注意力不集中无关;这种影响与性别无关。NOS 1-ex 1f也与女性几个主要WM束的MD值相关，但与男性无关。在女性中，短等位基因的纯合性与较长等位基因的携带者更高的MD值有关。这些区域的MD值与ADHD症状无关。有和没有ADHD的参与者的结果相似。NOS 1-ex 1f VNTR与ADHD和健康对照组女性参与者的WM微结构相关。这种关联是否是从NOS 1到ADHD症状的神经发育途径的一部分，应在未来的研究中进一步研究。
The nitric oxide synthase gene (NOS1) exon 1f (ex1f) VNTR is a known genetic risk factor for Attention-Deficit/Hyperactivity Disorder (ADHD), particularly in females. NOS1 plays an important role in neurite outgrowth and may thus influence brain development, specifically white matter (WM) microstructure, which is known to be altered in ADHD. The current study aimed to investigate whether NOS1 is associated with WM microstructure in (female) individuals with and without ADHD. Diffusion Tensor Imaging (DTI) scans were collected from 187 participants with ADHD (33% female) and 103 controls (50% female), aged 8–26 years, and NOS1-ex1f VNTR genotype was determined. Whole-brain analyses were conducted for fractional anisotropy (FA) and mean diffusivity (MD) to examine associations between NOS1 and WM microstructure, including possible interactions with gender and diagnosis. Consistent with previous literature, NOS1-ex1f was associated with total ADHD and hyperactivity-impulsivity symptoms, but not inattention; this effect was independent of gender. NOS1-ex1f was also associated with MD values in several major WM tracts in females, but not males. In females, homozygosity for the short allele was linked to higher MD values than carriership of the long allele. MD values in these regions did not correlate with ADHD symptoms. Results were similar for participants with and without ADHD. NOS1-ex1f VNTR is associated with WM microstructure in females in a large sample of participants with ADHD and healthy controls. Whether this association is part of a neurodevelopmental pathway from NOS1 to ADHD symptoms should be further investigated in future studies.
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影响因子：
5.3
作者：
Franke B;Neale BM;Faraone SV
通讯作者：
Faraone SV
影响因子：
1.7
作者：
Hamilton LS;Levitt JG;O'Neill J;Alger JR;Luders E;Phillips OR;Caplan R;Toga AW;McCracken J;Narr KL
通讯作者：
Narr KL
影响因子：
11
作者：
Franke, B.;Faraone, S. V.;Asherson, P.;Buitelaar, J.;Bau, C. H. D.;Ramos-Quiroga, J. A.;Mick, E.;Grevet, E. H.;Johansson, S.;Haavik, J.;Lesch, K-P;Cormand, B.;Reif, A.
通讯作者：
Reif, A.
影响因子：
3.3
作者：
Chen, J.;Zacharek, A.;Chopp, M.
通讯作者：
Chopp, M.
影响因子：
4.7
作者：
Kalisch, BE;Bock, NA;Rylett, RJ
通讯作者：
Rylett, RJ