An analysis of the cellular localization of cytochrome oxidase in the lateral geniculate nucleus of the adult cat
An analysis of the cellular localization of cytochrome oxidase in the lateral geniculate nucleus of the adult cat
复制标题
成年猫外侧膝状核细胞色素氧化酶的细胞定位分析
DOI：
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
M. Wong
中科院分区：
文献类型：
--
作者：
G. Kageyama;M. Wong
细胞色素氧化酶（C.O.）在正常成年猫外侧膝状体核的细胞和电镜水平上观察到一种新的神经元。X和/或Y感受板层的较暗反应性（A，A1，大细胞层C [Cm]和内侧层间核[MIN]）与轻度反应性W受体小细胞层C（Cp）相比，表明猫视觉系统中存在通路特异性组织化学差异。在细胞水平上，外侧膝状体核（LGN）中的深色反应性大细胞与1类细胞非常相似，Y细胞的相对大小和分布，因此表明C. O.组织化学可用作这些细胞的功能标记。周膝状体神经元也有暗反应。2、4和3类神经元（假定为X细胞、W细胞和/或中间神经元）具有中度至轻度反应性胞体。暗反应性神经元类倾向于接收相对较强的近端兴奋性突触输入比反应性较低的神经元类。由于所有神经元类别似乎都有深色（或中度）反应性树突，因此C.O.某些神经元类别的树突和索马之间的反应性必然不同。在电子显微镜水平上，神经元的不同成分往往具有特定水平的CO。反应性树突中深色反应性线粒体的优势表明树突的代谢非常活跃。RLD和许多F的，但很少有大轴突终端与圆泡（RL）或小轴突终端与圆泡（RS）的配置文件是深色反应，这意味着特定类别的突触前结构比其他更活跃。因此C.O.组织化学不仅可用于区分功能上活跃的神经元类别，如Y细胞和周膝状体（PG）神经元与较不活跃的神经元类别，而且可用于区分同一神经元的功能上或多或少活跃的部分，包括其树突、轴突和/或轴突终末。
The distribution of cytochrome oxidase (C.O.) was examined in the normal adult cat lateral geniculate nucleus at the cellular and electronmicroscopic levels. The darker reactivity of the X‐ and/or Y‐receptive laminae (A, A1, magnocellular lamina C [Cm], and medial interlaminar nucleus [MIN]) compared with the lightly reactive W‐receptive parvicellular lamina C (Cp) indicates that there are pathway‐specific histochemical differences in the visual system of the cat. At the cellular level, darkly reactive large cells in the lateral geniculate nucleus (LGN) closely resemble class 1, Y‐cells, in relative size and distribution, thus indicating that C.O. histochemistry may be used as a functional marker for these cells. Perigeniculate neurons are also darkly reactive. Neuronal classes 2, 4, and 3 (presumed X‐cells, W‐cells, and/or interneurons) have moderate to lightly reactive perikarya. The darkly reactive neuronal classes tend to receive relatively stronger proximal excitatory synaptic input than do the less reactive neuronal classes. Since all neuronal classes appeared to have darkly (or moderately) reactive dendrites, C.O. reactivity must differ between dendrite and soma of some neuronal classes. At the electron‐microscopic level, distinct components of the neuropil tend to have specific levels of C.O. reactivity. The predominance of darkly reactive mitochondria in dendrites indicates that dendrites are metabolically very active. RLD and many F's, but few large axon terminals with round vesicles (RL) or small axon terminals with round vesicles (RS) profiles are darkly reactive, implying that specific classes of presynaptic structures are more active than others. Thus C.O. histochemistry may be useful for distinguishing not only functionally active neuronal classes such as Y‐cells and perigeniculate (PG) neurons from less active neuronal classes, but also functionally more or less active parts of the same neuron including its dendrites, axons, and/or axon terminals.
影响因子：
33.6
作者：
通讯作者：
--
猫外侧膝状体核中浓缩外源性 [3H]-γ-氨基丁酸 (GABA) 的神经元。
DOI：
10.1002/cne.901920408
发表时间：
1980
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Sterling,P;Davis,TL
通讯作者：
Davis,TL